A marine biologist's adventurous life as a professor and mother in Alaska is upended when her healthy husband is slammed by a rare type of stroke. His radical approach to recovery clashes with her instinct to keep him safe at home and sets them on a collision course as he insists on ambitious sailing expeditions with Beth and their young son in Alaska's magnificent yet unforgiving waters.

After the tragic death of her husband, Sarah's life comes to a halt. She struggles with knowing she can no longer talk with him. She tries to find some happiness by turning to the Lord, but she still feels emptiness inside. She conceives a baby out of wedlock, and creates a child to hold the image of her late husband. She finds peacefulness in her life and uses her love and faith in Jesus Christ to rebuild an old church. Between her baby and church she feels whole again, and the ache in her heart dwindles. Then, her child's life is put in danger, and Sarah's faith is tested. Sarah finds her one true friend is holding a grudge over her husband's death. Secrets that should have been buried re-surface, and friendships turn sour. Can Sarah trust that the Lord will not take away the one thing that is holding her life together? A man enters her life and creates unwanted feelings, making her world take on strange turns. Can she trust him and accept his help, to insure her baby's safety? Can she survive the challenges that the Lord has set forth, or let go of her faith and fail? Can Sarah's faith reign over her uncertainties?

Kristen's secret is exposed, and now the Maddison family must decide if she should leave or stay. Kristen struggles with her faith, and finds simple pleasures difficult. She tries enjoying her freedom by searching for memories of her mom, but is afraid she has lost them for good. Katie continues fighting the tumor growing inside her, and questions her faith as new problems arise. Everyone tries supporting her and the changes the tumor creates. Complicating symptoms keep multiplying, some life threatening. She struggles with her feelings and questions her needs for Kurt, as her health declines. Kurt wants to guide Katie through her medical problems, proving to her how the Lord will provide her strength and keep her safe. He finds this journey difficult as he struggles with his own problems. He is mistaken as a convicted felon and is assaulted by a troubled officer. A hospital nurse becomes obsessed with Kurt and he finds himself in unfamiliar territory. The officer tries to find clues to save Kurt, his own job and the anger inside himself from when a stranger hurt his daughter. The officer is tested, when the same stranger goes after his wife. Can these young adults find the individual strength to fight the evil surrounding them? Can Katie embrace her beliefs, or pushes away as her health fails? Does she believe the Lord is with her? I Am with You is a silent reminder of how the Lord is by our side and how without Him we will not have eternal life.