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Completely revised and updated, Pharmaceutical Experimental Design
and Interpretation, Second Edition explains the major methods of
experimental design and evaluation such as multivariate,
sequential, and principal components analysis. With new sections on
neural networks, artificial intelligence, fractional designs, and
optimization techniques, this source will prove invaluable to
anyone involved in the design and execution of pharmaceutical
research studies and the interpretation of study data.
Completely updated, this new edition explains the major methods of
experimental design and evaluation such as multivariate,
sequential, and principal components analysis. It offers new
sections on neural networks, artificial intelligence, fractional
designs, and optimization techniques. Taking a practice-orientated
approach, it employs current case studies to illustrate important
concepts, so as to deliver a clear understanding of statistical
approaches without repeating information from older statistics
textbooks. It supplies appendices on statistical tables, computer
programs in BASIC and MINITAB Commands, sequential analysis grids,
and matrices.
A HISTORY OF THE MEDICINES WE TAKE gives a lively account of the
development of medicines from traces of herbs found with the
remains of Neanderthal man, to prescriptions written on clay
tablets from Mesopotamia in the third millennium BC, to pure drugs
extracted from plants in the nineteenth century to the latest
biotechnology antibody products. The first ten chapters of the book
in PART ONE give an account of the development of the active drugs
from herbs used in early medicine, many of which are still in use,
to the synthetic chemical drugs and modern biotechnology products.
The remaining eight chapters in PART TWO tell the story of the
developments in the preparations that patients take and their
inventors, such as Christopher Wren, who gave the first intravenous
injection in 1656, and William Brockedon who invented the tablet in
1843\. The book traces the changes in patterns of prescribing from
simple dosage forms, such as liquid mixtures, pills, ointments,
lotions, poultices, powders for treating wounds, inhalations, eye
drops, enemas, pessaries and suppositories mentioned in the
Egyptian Ebers papyrus of 1550 BCE to the complex tablets,
injections and inhalers in current use. Today nearly three-quarters
of medicines dispensed to patients are tablets and capsules. A
typical pharmacy now dispenses about as many prescriptions in a
working day as a mid-nineteenth- century chemist did in a whole
year.
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