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First developed as an accessible abridgement of the successful
"Handbook of Stem Cells," "Essentials of Stem Cell Biology" serves
the needs of the evolving population of scientists, researchers,
practitioners, and students embracing the latest advances in stem
cells. Representing the combined effort of 7 editors and more than
200 scholars and scientists whose pioneering work has defined our
understanding of stem cells, this book combines the prerequisites
for a general understanding of adult and embryonic stem cells with
a presentation by the world's experts of the latest research
information about specific organ systems. From basic
biology/mechanisms, early development, ectoderm, mesoderm,
endoderm, and methods to theapplication of stem cells to specific
human diseases, regulation and ethics, and patient perspectives, no
topic in the field of stem cells is left uncovered.
Contributions by Nobel Laureates and leading international
investigatorsIncludes two entirely new chapters devoted exclusively
to induced pluripotent stem (iPS) cells written by the scientists
who made the breakthroughEdited by a world-renowned author and
researcher to present a complete story of stem cells in research,
in application, and as the subject of political debatePresented in
full color with a glossary, highlighted terms, and bibliographic
entries replacing references"
New discoveries in the field of stem cells increasingly dominate
the news and scientific literature revealing an avalanche of new
knowledge and research tools that are producing therapies for
cancer, heart disease, diabetes, and a wide variety of other
diseases that afflict humanity. The Handbook of Stem Cells
integrates this exciting area of life science, combining in two
volumes the requisites for a general understanding of adult and
embryonic stem cells. Organized in two volumes entitled Pluripotent
Stem Cells & Cell Biology and Adult & Fetal Stem Cells,
this work contains contributions from the world s experts in stem
cell research to provide a description of the tools, methods, and
experimental protocols needed to study and characterize stem cells
and progenitor populations as well as a the latest information of
what is known about each specific organ system.
* Provides comprehensive coverage on this highly topical
subject
* Contains contributions by the foremost authorities and premiere
names in the field of stem cell research
*Companion website - http: //booksite.elsevier.com/9780123859426/-
containsover 250 color figures in presentation format"
Miniaturization in the fields of chemistry and molecular biology
has resulted in the "lab-on-a-chip." Such systems are
micro-fabricated devices capable of handling extremely small fluid
volumes facilitating the scaling of single or multiple lab
processes down to a microchip-sized format. The convergence of
lab-on-a-chip technology with the field of cell biology facilitated
the development of "organ-on-a-chip" systems. Such systems simulate
the function of tissues and organs, having the potential to bypass
some cell and animal testing methods. These technologies have
generated high interest as applications for disease modeling and
drug discovery. This book, edited by Drs. Sean Murphy and Anthony
Atala, provides a comprehensive coverage of the technologies that
have been used to develop organ-on-a-chip systems. Known leaders
cover the basics to the most relevant and novel topics in the
field, including micro-fabrication, 3D bio-printing, 3D cell
culture techniques, biosensor design and microelectronics,
micro-fluidics, data collection, and predictive analysis. The book
describes specific tissue types amenable for disease modeling and
drug discovery applications. Lung, liver, heart, skin and kidney
"on-a-chip" technologies are included as well as a progress report
on designing an entire "body-on-a-chip" system. Additionally, the
book covers applications of various systems for modeling
tissue-specific cancers, metastasis, and tumor microenvironments;
and provides an overview of current and potential applications of
these systems to disease modeling, toxicity testing, and
individualized medicine.
This body of work represents the first volume of a book series
covering the field of tissue engineering. Tissue engineering, which
refers to a category of therapeutic or diagnostic products and
processes which are based upon a combination of living cells and
biomaterials, was defined as a field only a few years ago (1988).
Tissue engineering is an inherently interdisciplinary field,
combining bioengineering, life sciences and clinical sciences. The
definition of this area of work as the field of tissue engineering
brought together scientists from multiple backgrounds who already
were working toward the achievement of similar goals. Why a book
series exclusively devoted to tissue engineering? The field of
tissue engineering is heterogeneous. The cells involved in tissue
engineering can be autologous, allogeneic or xenogeneic. The
biomaterials utilized can be either naturally occurring, synthetic
or a combination of both. The appli cation of the technology can be
either for acute or permanent purposes. An attempt to cover the
field of tissue engineering in a single volume, with the degree of
detail necessary for individuals with different scientific back
grounds and disciplines, would be a difficult task to accomplish,
particularly when this field is just emerging and changing rapidly.
Therefore, addressing different technologies within the field of
tissue engineering, in a comprehen sive manner, is the main mission
of this series of volumes. A stellar group of scientists has been
brought together to form the editorial board of the series."
Translating Regenerative Medicine to the Clinic reviews the current
methodological tools and experimental approaches used by leading
translational researchers, discussing the uses of regenerative
medicine for different disease treatment areas, including
cardiovascular disease, muscle regeneration, and regeneration of
the bone and skin. Pedagogically, the book concentrates on the
latest knowledge, laboratory techniques, and experimental
approaches used by translational research leaders in this field. It
promotes cross-disciplinary communication between the
sub-specialties of medicine, but remains unified in theme by
emphasizing recent innovations, critical barriers to progress, the
new tools that are being used to overcome them, and specific areas
of research that require additional study to advance the field as a
whole. Volumes in the series include Translating Gene Therapy to
the Clinic, Translating Regenerative Medicine to the Clinic,
Translating MicroRNAs to the Clinic, Translating Biomarkers to the
Clinic, and Translating Epigenetics to the Clinic.
Translational Regenerative Medicine is a reference book that
outlines the life cycle for effective implementation of discoveries
in the dynamic field of regenerative medicine. By addressing
science, technology, development, regulatory, manufacturing,
intellectual property, investment, financial, and clinical aspects
of the field, this work takes a holistic look at the translation of
science and disseminates knowledge for practical use of
regenerative medicine tools, therapeutics, and diagnostics.
Incorporating contributions from leaders in the fields of
translational science across academia, industry, and government,
this book establishes a more fluid transition for rapid translation
of research to enhance human health and well-being.
This body of work represents the first volume of a book series
covering the field of tissue engineering. Tissue engineering, which
refers to a category of therapeutic or diagnostic products and
processes which are based upon a combination of living cells and
biomaterials, was defined as a field only a few years ago (1988).
Tissue engineering is an inherently interdisciplinary field,
combining bioengineering, life sciences and clinical sciences. The
definition of this area of work as the field of tissue engineering
brought together scientists from multiple backgrounds who already
were working toward the achievement of similar goals. Why a book
series exclusively devoted to tissue engineering? The field of
tissue engineering is heterogeneous. The cells involved in tissue
engineering can be autologous, allogeneic or xenogeneic. The
biomaterials utilized can be either naturally occurring, synthetic
or a combination of both. The appli cation of the technology can be
either for acute or permanent purposes. An attempt to cover the
field of tissue engineering in a single volume, with the degree of
detail necessary for individuals with different scientific back
grounds and disciplines, would be a difficult task to accomplish,
particularly when this field is just emerging and changing rapidly.
Therefore, addressing different technologies within the field of
tissue engineering, in a comprehen sive manner, is the main mission
of this series of volumes. A stellar group of scientists has been
brought together to form the editorial board of the series."
Principles of Regenerative Medicine, Third Edition, details the
technologies and advances applied in recent years to strategies for
healing and generating tissue. Contributions from a stellar cast of
researchers cover the biological and molecular basis of
regenerative medicine, highlighting stem cells, wound healing and
cell and tissue development. Advances in cell and tissue therapy,
including replacement of tissues and organs damaged by disease and
previously untreatable conditions, such as diabetes, heart disease,
liver disease and renal failure are also incorporated to provide a
view to the future and framework for additional studies.
In 1996, the National Bladder Foundation (NBF) was founded by a
dedicated group of physicians and researchers propeIled by the
urgent need to find better treatments for bladder disease.
Committed to increasing bladder disease research and to supporting
its research community, the NBF coordinates and sponsors the
International Bladder Symposium (IBS) in Washington, DC. Now
considered to be a premier scientific assembly, the IBS brings
together international leaders in bladder disease research to
present and discuss their findings. It is the only international
conference where all areas of bladder disease research are
exclusively covered and where bladder disease researchers are
provided with a unique opportunity to share their results and
theories. IBS participants contributed the research papers included
in this publication in 2000 and 2001. AIl substantial areas of
bladder disease research are addressed, including oncology and
ceIlular biology, neurophysiology, neurogenic bladder and
incontinence, immunology, inflammation and infection, muscle,
matrix and obstruction, and new frontiers and therapies of the
bladder. Assembled in one publication, these papers and their
findings demonstrate the high scientific caliber of the dedicated
researchers in this field and the potential for significant
discoveries in treatment options in the next decade.
Perinatal Stem Cells provides researchers and clinicians with a
comprehensive description of the current clinical and pre-clinical
applications of stem cells derived from perinatal sources, such as
amniotic fluid, placenta and placental membranes, the umbilical
cord and Wharton's jelly. It's compiled by leading experts in the
field, offering readers detailed insights into sources of perinatal
stem cells and their potential for disease treatment. Therapeutic
applications of perinatal stem cells include the treatment of in
utero and pregnancy related diseases, cardiac disease, liver
disease, pulmonary disease, inflammatory diseases, for
hematopoietic regeneration, and for neural protection after stroke
or traumatic brain injury. In addition, the rapid advance in
clinical translation and commercialization of perinatal stem cell
therapies is highlighted in a section on Clinical and Industry
Perspective which provides insight into the new opportunities and
challenges involved in this novel and exciting industry.
In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial
Design explores the body's ability to mobilize endogenous stem
cells to the site of injury and details the latest strategies
developed for inducing and supporting the body's own regenerating
capacity. From the perspective of regenerative medicine and tissue
engineering, this book describes the mechanism of host cell
recruitment, cell sourcing, cellular and molecular roles in cell
differentiation, navigational cues and niche signals, and a
tissue-specific smart biomaterial system that can be applied to a
wide range of therapies. The work is divided into four sections to
provide a thorough overview and helpful hints for future
discoveries: endogenous cell sources; biochemical and physical
cues; smart biomaterial development; and applications.
Handbook of Tissue Engineering Scaffolds: Volume Two provides a
comprehensive and authoritative review on recent advancements in
the application and use of composite scaffolds in tissue
engineering. Chapters focus on specific tissue/organ (mostly on the
structure and anatomy), the materials used for treatment, natural
composite scaffolds, synthetic composite scaffolds, fabrication
techniques, innovative materials and approaches for scaffolds
preparation, host response to the scaffolds, challenges and future
perspectives, and more. Bringing all the information together in
one major reference, the authors systematically review and
summarize recent research findings, thus providing an in-depth
understanding of scaffold use in different body systems.
Handbook of Tissue Engineering Scaffolds: Volume One, provides a
comprehensive and authoritative review on recent advancements in
the application and use of composite scaffolds in tissue
engineering. Chapters focus on specific tissue/organ (mostly on the
structure and anatomy), the materials used for treatment, natural
composite scaffolds, synthetic composite scaffolds, fabrication
techniques, innovative materials and approaches for scaffolds
preparation, host response to the scaffolds, challenges and future
perspectives, and more. Bringing all the information together in
one major reference, the authors systematically review and
summarize recent research findings, thus providing an in-depth
understanding of scaffold use in different body systems.
Essentials of 3D Biofabrication and Translation discusses the
techniques that are making bioprinting a viable alternative in
regenerative medicine. The book runs the gamut of topics related to
the subject, including hydrogels and polymers, nanotechnology,
toxicity testing, and drug screening platforms, also introducing
current applications in the cardiac, skeletal, and nervous systems,
and organ construction. Leaders in clinical medicine and
translational science provide a global perspective of the
transformative nature of this field, including the use of cells,
biomaterials, and macromolecules to create basic building blocks of
tissues and organs, all of which are driving the field of
biofabrication to transform regenerative medicine.
Miniaturization in the fields of chemistry and molecular biology
has resulted in the "lab-on-a-chip." Such systems are
micro-fabricated devices capable of handling extremely small fluid
volumes facilitating the scaling of single or multiple lab
processes down to a microchip-sized format. The convergence of
lab-on-a-chip technology with the field of cell biology facilitated
the development of "organ-on-a-chip" systems. Such systems simulate
the function of tissues and organs, having the potential to bypass
some cell and animal testing methods. These technologies have
generated high interest as applications for disease modeling and
drug discovery. This book, edited by Drs. Sean Murphy and Anthony
Atala, provides a comprehensive coverage of the technologies that
have been used to develop organ-on-a-chip systems. Known leaders
cover the basics to the most relevant and novel topics in the
field, including micro-fabrication, 3D bio-printing, 3D cell
culture techniques, biosensor design and microelectronics,
micro-fluidics, data collection, and predictive analysis. The book
describes specific tissue types amenable for disease modeling and
drug discovery applications. Lung, liver, heart, skin and kidney
"on-a-chip" technologies are included as well as a progress report
on designing an entire "body-on-a-chip" system. Additionally, the
book covers applications of various systems for modeling
tissue-specific cancers, metastasis, and tumor microenvironments;
and provides an overview of current and potential applications of
these systems to disease modeling, toxicity testing, and
individualized medicine.
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