This book integrates recent advances in molecular and cell biology of hematopoietic stem cells (HSC) with developments in clinical research in stem cell-based therapy-providing an up-to-date review of novel cytokines and cellular components; animal models; cell preparation, selection, and collection; minimal residual disease and purging; expansion of progenitor cells; allogeneic and autologous transplantation; cellular gene and immunotherapy; and more. Examines key areas for treatment with HSC, including ambulatory care and monitoring, regimen-related toxicities, immunodeficiency and immunization, infection, chronic graft-versus-host and disease, secondary malignancies, and long-term quality of life. Covering stem cell pool regulation and the complex interplay of extrinsic and intrinsic events, Hematopoietic Stem Cell Transplantation summarizes current understanding and development of clinical allogeneic HSC transplantation discusses the use of allogeneic transplantations with reduced conditioning regimen or mini-transplantation considers various strategies for mobilization of HSCs from peripheral blood (PB) of normal donors details detection of bone marrow contamination by tumor cells and removal procedures focuses on efforts to increase the ex vivo transduction efficiency of human HSCs with retroviral vectors explores the effects of growth factor administration and leukapheresis on PB stem cell donors shows the impact of CD34+ cell isolation and the relevance of expansion of HSC from bone marrow for clinical use reveals how minimal residue disease detection assays are crucial for tracking the clinical significance of infused tumor cells employs automated fluorescence image cytometry to study early HSC behavior following seeding Incorporating contributions from over 90 researchers who cite more than 2180 references to encourage continued study,

This book integrates recent advances in molecular and cell biology of hematopoietic stem cells (HSC) with developments in clinical research in stem cell-based therapy-providing an up-to-date review of novel cytokines and cellular components; animal models; cell preparation, selection, and collection; minimal residual disease and purging; expansion of progenitor cells; allogeneic and autologous transplantation; cellular gene and immunotherapy; and more. Examines key areas for treatment with HSC, including ambulatory care and monitoring, regimen-related toxicities, immunodeficiency and immunization, infection, chronic graft-versus-host and disease, secondary malignancies, and long-term quality of life. Covering stem cell pool regulation and the complex interplay of extrinsic and intrinsic events, Hematopoietic Stem Cell Transplantation -summarizes current understanding and development of clinical allogeneic HSC transplantation -discusses the use of allogeneic transplantations with reduced conditioning regimen or mini-transplantation -considers various strategies for mobilization of HSCs from peripheral blood (PB) of normal donors -details detection of bone marrow contamination by tumor cells and removal procedures -focuses on efforts to increase the ex vivo transduction efficiency of human HSCs with retroviral vectors -explores the effects of growth factor administration and leukapheresis on PB stem cell donors -shows the impact of CD34+ cell isolation and the relevance of expansion of HSC from bone marrow for clinical use -reveals how minimal residue disease detection assays are crucial for tracking the clinical significance of infused tumor cells -employs automated fluorescence imagecytometry to study early HSC behavior following seeding Incorporating contributions from over 90 researchers who cite more than 2180 references to encourage continued study, Hematopoietic Stem Cell Transplantation is a blue-chip reference for hematologists, hematopathologists, oncologists, cytotherapists, transplantation immunologists, and molecular biologists.

Dies ist ein Open Access Buch. Wir haben immer mehr Alte, immer weniger Kinder. Dank wissenschaftlicher Fortschritte verlangert sich die Lebenserwartung standig. Erkenntnisse aus der Naturwissenschaft in der post-genomischen AEra deuten darauf, dass diese Entwicklung trotz der Zunahme altersassoziierter Krankheiten und Behinderungen noch nicht am Ende angekommen ist. Droht diese Flut von Alten, Rentnern und "Konsumenten des Lebens" zum Verlust des Zusammenhalts der Gesellschaft zu fuhren? Nach der Bestandsaufnahme der jungsten Errungenschaften der Forschung hat das interaktive Symposium sich mit den Chancen und Gefahren der "gewonnenen Jahre" auseinandergesetzt. Die Referentinnen und Referenten sind herausragende Vertreter der Biologie und Medizin. Meinungsbildner der Geisteswissenschaften und Persoenlichkeiten aus der Politik kamen ebenfalls zu Wort.Dies ist ein Open-Access-Buch.