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The current anti-cancer synthetic medicines are inefficient and
unsafe. The plants-based lead molecules such as taxol,
camptothecin, podophyllotoxins, vinblastine, vincristine,
homoharringtonine and numerous other anticancer compounds from
Nature’s arsenal are potentially safe and powerful alternative
means that effectively fight against cancer. The volume looks at a
variety of medicinal plants and approaches that have beneficial
results against cancer. Topics include Unani approaches of
anticancer plants, genetic engineering and CRISPR/CAS-mediated
editing to enhance anticancer potential, computational approaches
used in anticancer plants, and more. The volume also examines the
metabolomics of plants that give them anti-cancer properties. This
volume, Plant-Derived Anticancer Drugs in the OMICS Era:
Biosynthesis, Function, and Applications, will be valuable to
cancer researchers and drug developers among others.
Herbal medicines play a critical role in the prevention and
treatment of cancer disorders, which are a foremost cause of human
disease and death worldwide. This new volume provides a wealth of
valuable information on the most vital plant genera and species
that have potent anticancer activities, namely Garcinia indica,
Centella asiatica Linn, Nigella sativa, Ocimum sanctum, Boswellia
serrata Roxb, Catharanthus roseus, Withania somnifera (Linn.)
Dunal, Camptotheca acuminata Decne, Taxus baccata L., Panax
ginseng, Tinospora cordifolia (Wild) Miers, Taxus brevifolia, and
Glycyrrhiza glabra. These anticancer medicinal plants are bestowed
with a novel and essential array of chemotherapeutic complexes,
biologically active molecules, and secondary metabolites (such as
taxol, vinblastine, vincristine, camptothecin, topotecan, etc.)
with promising properties to cure cancer in humans. These plants
show a vast potential for new drug discovery in the era of modern
medicine to fight against cancer. Key features of the book:
Provides knowledge of secondary metabolite profiling, active
ingredients, modes of action, and pharmacological outcomes of
various anticancer plants Discusses the potential of important
anticancer plants at the global level Offers information to promote
the discovery of new drugs from anticancer plants This book will be
valuable to oncologists, cancer researchers, biotechnologists,
medicinal chemists, pharmacists, pharmacologists, phytochemists,
members of biomedical and pharmaceutical sciences working in the
areas of cancer treatment, and upper-level students and residents
in pharmacy and medicine.
With the increase in global climate change and challenges to
agriculture, this book will be valuable gem for understanding the
regulatory networks of stress responsive genes and miRNome.
Companies working on engineered plants can take a cue from this
book for designing of climate resilient crops. The book will prove
as an important chaperon for postgraduate students, teachers, and
plant science researchers, scientists in academia and private
sector and industries. No such book with compiled knowledge on
stress associated microRNAs is available. The book will prove as an
important for University and College teachers, and plant science
researchers, biotechnologists, bioinformaticians, biochemists,
scientists in academia and private sectors.
This volume takes an in-depth look at the potential pharmacological
applications of 11 important antidiabetic plants, examining their
antihyperglycemic, hypoglycemic, and anti-lipidemic properties
along with current genome editing research perspectives. Plant
natural products, or phytoconstituents, are promising candidates
for antidiabetic pharmacological actions. The phytoconstituents,
such as i' avonoids, terpenoids, saponins, carotenoids, alkaloids
and glycosides, play vital roles in the current and future potent
antidiabetic drug development programs Each chapter reviews a
particular plant with antidiabetic properties, explaining the
therapeutic aspects, its active antidiabetic compounds, and
relevant genome editing technology. The specific plants discussed
include Azadirachta indica (commonly known as neem, nimtree or
Indian lilac), Gymnema sylvestre (commonly called gymnema,
Australian cowplant, and Periploca of the woods), Syzygium cumini
(commonly known as Malabar plum, Java plum, black plum, jamun or
jambolana), Ceylon cinnamon (or true cinnamon, as opposed to cassia
cinnamon), insulin plant (or Costus pictus), Trigonella
foenum-graecum (better known as fenugreek), Mulberry, Nigella
sativa L. (black caraway, also known as black cumin, nigella,
kalojeera, kalonji or kalanji), Aegle marmelos (L.) (commonly known
as bael (or bili or bhel), also Bengal quince, golden apple,
Japanese bitter orange, stone apple or wood apple), Ficus
benghalensis (the banyan, banyan fig and Indian banyan), and of
course, garlic (Allium sativum). Antidiabetic Plants for Drug
Discovery: Pharmacology, Secondary Metabolite Profiling, and
Ingredients with Insulin Mimetic Activity will serve as a valuable
source of information for students, drug researchers, medical
practitioners, diabetic patients, and many others in the effort to
gain understand of how these plant drug molecules can help fight
diabetes.
The book provides an informative overview of diabetes mellitus in
conjunction with current plant-based treatments for this disease
and available methods for studying the antidiabetic activities of
scientifically developed plant products, mechanisms of action,
their therapeutic superiority, and current genome editing research
perspectives and biotechnological approaches. The book begins with
an introduction to diabetes, giving an overview of the history,
diagnosis, classification, pathophysiology, and risk factors. It
goes on to review traditional uses of plants for diabetes along
with some ethnobotanical information as well. The results of
scientific studies on the various modes of action of antidiabetic
plants are discussed, such as the molecular aspects active
plant-based antidiabetic drug molecules. A section featuring recent
biotechnological advancements of antidiabetic plants and
plant-based antidiabetic drugs covers advances in molecular
breeding and application of molecular markers, biotechnologically
engineered transgenic medicinal plants, and advances in genomic
editing tools and techniques. This volume will be helpful for
researchers, medical practitioners, academicians, students in the
study of plant-based treatments for the treatment of diabetes
mellitus.
Provides knowledge on mushrooms as nutraceuticals and functional
foods. It will benefit both the direct and indirect audiences.
Reviews the health benefit of mushrooms. It is the only vegetarian
source of Vitamin D and mushroom industry. If cultivator understand
the health benefits, they can cultivate them accordingly. Doctors
can recommend these to patients.
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