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Models of Seizures and Epilepsy, Second Edition, is a valuable,
practical reference for investigators who are searching for the
most appropriate laboratory models to address key questions in the
field. The book also provides an important background for
physicians, fellows, and students, offering insight into the
potential for advances in epilepsy research as well as R&D drug
development. Contents include the current spectrum of models
available to model different epilepsy syndromes, epilepsy in
transgenic animals, comorbidities in models of epilepsy, and novel
technologies to study seizures and epilepsies in animals.
Stay current with recent progress in the field of acute
encephalopathy and encephalitis in infants with this practical
resource by Drs. Hideo Yamanouchi, Solomon L. Moshe, and Akihisa
Okumura. This practical resource covers key information relevant to
physicians, surgeons, and nurses who often must take prompt action
in the everyday clinical care of patients with these disorders.
Features a wealth of information for all health care professionals
who encounter these complex conditions. Covers diagnostic strategy,
subtypes of acute encephalopathy, and management of acute
encephalopathy and encephalitis. Consolidates today's available
information and guidance on acute encephalopathy and encephalitis
in infancy, in addition to related disorders, into one convenient
resource.
Seizures are more common early in life than in adulthood.
Bidirectional interactions between seizures and normal
developmental processes define their expression and outcomes.
Several developmentally regulated factors control neuronal
excitability. GABAA receptors hold a central role as they control
neuronal activity in an age-specific manner. Early in development,
GABAA receptors have depolarizing effects, which contribute to the
increased susceptibility of immature neurons to seizures but they
are also essential for normal brain development. During
development, there is a gradual shift to the "adult-type"
hyperpolarizing GABAA receptor signaling, creating more efficient
inhibition. Seizures may disrupt GABAA receptor signaling by
changing the expression of their subunits and by changing the
direction of GABAA responses, which, in certain situations, may be
detrimental for brain development. Furthermore, subcortical nuclei,
such as the substantia nigra, control the expression and
propagation of seizures in an age- and sex-dependent manner. These
endogenous control centers and signaling pathways are further
modified by independent genetic epigenetic, biologic, or other
factors, which further increase the heterogeneity in presentation
of seizures, their treatment, and their comorbidities. Elucidation
of these complex interactions and identification of biomarkers
guiding therapeutic interventions will be necessary to improve our
ability to treat early-life epilepsies.
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