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An intimate relation between hormones and lipoprotein metabolism
has been known for a long time especially from hormone-deficiency
or -overproduction syndromes. The mechanisms through which hormones
influence lipid metabolism have become a field of major interest in
sci ence. The more we learn about cellular hormonal actions the
better we understand regulatory processes and phenomena occuring in
patients. The present book summarizes data discussed at an
International Meet ing at Marburg, Germany, on "Hormones in
Lipoprotein Metabolism." It was an attempt to pull together
knowledge in basic science from the mode of action of hormones all
the way to clinical appearance of hor monal disorders involving
lipoprotein metabolism. Thus data on molec ular biology, on
hormonal regulation of apolipoprotein synthesis, on lipoprotein
receptors and enzyme induction are discussed together with the
large field of oral contraceptive use, postmenopausal estrogen sub
stitution, lipid disorders in diabetes mellitus, in thyroid
dysfunction, in adrenal insufficiency and in glucocorticoid
application. We are aware of the fact that such an overview cannot
be complete but should serve as a collection of data and ideas for
those interested in hormonal regulation of lipid metabolism. We
thank all authors for taking an extra effort in writing up their
presentations and thus making this edition possible. We also thank
Bristol-Myers-Squibb for generous support of the meeting and of the
final publication. Marburg, Germany ARMIN STEINMETZ JURGEN
SCHNEIDER HANS KAFFARNIK Contents Molecular Biology Chairmen: D. J.
Rader, A."
A number of clinical and epidemiological studies have shown that
disorders of lipoprotein metabolism constitute one of the most
important risk factors for the development of atherosclerosis and
coronary heart disease. This volume examines the state of the art
of lipoprotein subclass metabolism and its relation to these
diseases. The authors also report on new developments concerning
the role of lipoprotein recptors, macrophages and apolipoprotein E
polymorphism in cholesterol homeostasis. The combination of general
outline form and very specific aspects of cholesterol transport
will interest those in other disciplines following developments in
the field, as well as those directly involved in lipoprotein
research.
Die Ressourcen im Gesundheitswesen stehen vor einschneidenden
Einschr{nkungen. Das zwingt in der Praxis dazu, die M-glichkeiten
der prim{ren und sekund{ren Pr{vention gezielt einzusetzen. Die
hier vorgelegten Beitr{ge erm-glichen die Beurteilung, ob die
Behandlung einer Fettstoffwechselst-rung sinnvoll, erforderlich und
m-glich ist und mit welchen Ma nahmen bis zu welchen Zielwerten sie
durchgef}hrt werden kann.
Fettstoffwechselstorungen gehoren mit zu den Hauptrisikofaktoren
fur die Entstehung der koronaren Herzkrankheit. Das vorliegende
Buch enthalt aktuelle Richtwerte zur Behandlung der
Hyperlipoproteinamien und neuzeitliche diatetische und
medikamentose Therapieprinzipien einschliesslich der
extrakorporalen LDL-Elimination. Ausserdem werden die rheologischen
Begleiteffekte einer lipidsenkenden Therapie sowie die
Behandlungsmoglichkeiten im Kindesalter besprochen.
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