This collection aims to examine the relationship between American fiction and innovations that marked the first decades of the 21st century: the Internet, social media, smart objects and environments, artificial intelligence, nanotechnologies, genetic engineering and other biotechnologies, transhumanism. These technological innovations redefine the way we live in and imagine our world, interact with each other and understand the human being in his or her ever closer relationship to the machine a human being no longer, as in the past, cared for or repaired, but now enhanced or replaced. What about our artistic and cultural practices? Are these recent advances changing language and literature? How is fiction transformed by technological progress and what representations of progress can it oppose? Can fiction offer a critique of the new media and the upheavals they precipitate? How does the temporality of literature respond to a technical time subjected to the imperative of efficiency, where the present is a slave to the future? Do virtual worlds challenge the primacy of literary fiction as a privileged mode of escape from daily life? In a context where software can generate literary works, can the force of poetical advent still oppose algorithmic logics? What becomes of the body in a world in which its technical extensions increase the externalization of its cognitive functions in media artifacts and digital networks? In order to explore these questions, scholars here investigate the American fiction of Russel Banks, Don DeLillo, David Foster Wallace, Jonathan Lethem, Tao Lin, Richard Powers, Kenneth Goldsmith, Jennifer Egan or Jonathan Franzen as well as the Cyberpunk genre and the Neuronovel.