Introduction; Y. AlDoory. Taxonomy and Biology of Blastomyces Dermatitidis; A.M. Sugar. Virulence of Blastomyces Dermatitidis; E. Brummer. The Ecology of Blastomyces Dermatitidis; A.F. DiSalvo. The Epidemiology of Blastomycosis; A.F. DiSalvo. Diagnosis of Blastomycosis; N.L. Goodman. Immunodiagnosis of Blastomycosis; L. Kaufman. Immunology of Blastomycosis; B.S. Klien. Clinical Aspects of Blastomycosis; W.B. Causey, G.D. Campbell. Pathologic Features of Blastomycosis; F.W. Chandler, J.C. Watts. Experimental Blastomycosis; G.C. Cozad. Prognosis and Therapy of Blastomycosis; R.W. Bradsher. Blastomycosis in Animals; A.M. Legendre. Index.

Blastomycosis remains the most enigmatic of human mycotic infections. The enigmas encompass the natural habitat of the etiologic agent, extent of exposure and subclinical infections in endemic areas, distribution of en demic foci throughout the world, inconsistency of serologic evaluation of infected patients, and varying response of such patients to standard treat ment regimens. In spite of diligent investigations by many competent investigators, we still do not know the ecological niche inhabited by the etiologic agent. We have many tantalizing clues but no definite answers. Nor do we know the extent of the endemic areas in the world for this disease. Skin testing, so useful in defining the distribution of histoplasmosis and coccidioidomycosis, has been of no value in mapping endemic areas for blastomycosis. Even the serologic evaluation of known cases of the disease has been too erratic in results to be useful as a diagnostic or prognostic procedure. The enigmas of blastomycosis go straight to the disease itself. There is an extensive literature on the debate concerning the presence and extent of subclinical infections. Case report series demonstrate that such transient infections do occur but, unlike other mycoses, the extent to which this phe nomenon is common in the general population still cannot be assessed. Even the diagnosis of established disease is a major clinical problem.