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Heterocycles are ubiquitously present in nature and occupy a unique
place in organic chemistry as they are part of the DNA and
haemoglobin that make life possible. The Chemistry of Heterocycles
covers an introduction to the topic, followed by a chapter on the
nomenclature of all classes of isolated, fused and polycyclic
heterocycles. The third chapter delineates the highly strained
three membered N,O and S containing aromatic and non-aromatic
heterocycles with one and more than one similar and dissimilar
heteroatom. The four-membered heterocycles are abundantly present
in various natural and synthetic products of pharmacological
importance. This chapter describes the natural abundance,
synthesis, chemical reactivity, structural features and their
medicinal importance. This class of compounds are present as
sub-structures in penicillin and cytotoxic Taxol. Lastly, a chapter
on the natural abundance, synthesis, chemical reactivity and
pharmacological importance of 5-membered heterocycles with N,O,S
heteroatom is covered. The chemistry of heterocycles with mixed
heteroatom such as, N-S, N-O, N-S etc. is also described.
The Chemistry of Heterocycles: Chemistry of Six to Eight Membered
N,O, S, P and Se Heterocycles details the chemistry, behavior and
potential of these important structures. The book presents a
practical guide to international nomenclature, including
discussions of fused ring systems, heteroatoms with abnormal
valences, and bridged, spiro and polycyclic heterocycles. Three
membered heterocycles are then the focus, along with their
thermodynamic properties and importance in natural products,
medicines, materials, and their unique aspects, such as strain,
basicity and reactivity. Additional chapters cover 100 key
heterocycle structures, from Azetidines, Pyrroles and Pyridines, to
Benzoxepines and Oxocanes. Final chapters explore cutting-edge
advances in the development of phosphorus and selenium based
heterocycles.
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