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Silymarin is a purified extract from milk thistle (Silybum marianun
(L.) Gaertn), composed of a mixture of isomeric flavonolignans:
silybin (its main, active component), isosilybin, silydianin and
silychristin. This extract has been empirically used as a remedy
for almost 2000 years, and remains being used as a medicine for
many types of acute and chronic liver diseases. Despite its
routinely clinical use as hepatoprotectant, the mechanisms
underlying its beneficial effects remain largely unknown. The
purpose of this study was to investigate the pharmacokinetics and
bioaequivalence of two brands of Silymarin tablets in healthy male
volunteers in local population. Pharmacokinetic parameters were
calculated by non- compartmental method using Kinetica(r) PK/PD
version 4.4 and MS Excel Windows professional XP. Maximum
concentration of Silymarin in plasma (Cmax), time to these peak
plasma concentrations (Tmax) and other bioparameters (AUC0-,
AUMC0-, t1/2, Ke, MRT, Vd and ClT) were determine
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