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The present investigation was designed with an aim to formulate
Chitosan (CH) films by cross-linking with Sodium citrate (Nacit),
Sodium tripolyphosphate (NaTPP) or Chondroitin sulphate (CS) that
shall be capable of simulating the in vitro permeation of model
polar drug, 5-Fluorouracil (5-FU) and non polar drug, Indomethacin
(INDO) across rat/rabbit or human epidermis. Optimization design
was employed to identify and optimize various process and
formulation variables significantly (p
Colonic microflora is recognized as a preferable triggering
component in the design of colon specific drug delivery systems
since there is an abrupt increase of the bacterial population and
corresponding enzyme activities in the colon. The metabolism of
plant polysaccharides by microflora of large intestine has been
extensively investigated. However, these polysaccharides in their
putative form are soluble in acidic pH of stomach. Therefore,
investigations have been carried out to use modified or cross
linked polysaccharides for preventing drug release from dosage
forms in the stomach. This book deals with colon targeting of
corticosteroid for treatment of inflammatory bowel disease
employing interpolymer complex between natural polymers. The
interpolymer complexed films can be used for coating tablets that
can effectively deliver the drugs to colon. This book should be
especially useful to the researchers aiming to design dosage forms
for delivering drugs in the colon either for local action or for
increasing the absorption.Shorttitle
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