This book constitutes the proceedings of the 11th International Conference on Computational Methods in Systems Biology, CMSB 2013, held in Klosterneuburg, Austria, in September 2013. The 15 regular papers included in this volume were carefully reviewed and selected from 27 submissions. They deal with computational models for all levels, from molecular and cellular, to organs and entire organisms.

This work describes the fundamentals of CORDIC (Co- ordinate rotation Digital Computer) algorithm and how CORDIC algorithm can be used to calculate the trigonometric functions (Sine and Cosine) in circular rotation mode. The value of Sine and cosine functions are calculated in IEEE-754-1985 standardized single precision floating point format for better precision, accuracy and portability in the result. A normalization scheme is used which reduces error and requires no extra hardware. The trigonometric function values calculated using CORDIC algorithm are implemented in VHDL (Very High Speed Hardware Description Language), including language and design issues. The algorithm has been implemented in FPGA using VHDL.