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Models of Seizures and Epilepsy, Second Edition, is a valuable,
practical reference for investigators who are searching for the
most appropriate laboratory models to address key questions in the
field. The book also provides an important background for
physicians, fellows, and students, offering insight into the
potential for advances in epilepsy research as well as R&D drug
development. Contents include the current spectrum of models
available to model different epilepsy syndromes, epilepsy in
transgenic animals, comorbidities in models of epilepsy, and novel
technologies to study seizures and epilepsies in animals.
In the central nervous system, extracellular matrix (ECM)
molecules, including hyaluronic acid, chondroitin and heparan
sulfate proteoglycans, tenascins, reelin and agrin, along with
their remodelling enzymes, such as neurotrypsin, neuropsin,
plasminogen activators, and metalloproteinases, are secreted by
neural and non-neural cells into the extracellular space to form
the ECM and signal via ECM receptors. Despite recent advances in
the ECM field, the importance of neural ECM for physiological and
pathological processes is currently less widely recognized than
that of other CNS elements. This book will enlighten recent
progress in our understanding of mechanisms by which neural ECM,
its receptors and activity-dependent ECM remodeling regulate neural
development, synaptic plasticity, and contribute to pathological
changes in the brain. In the first part, the roles of ECM signaling
and proteolytic modification of ECM in neurogenesis, neural
migration, axonal pathfinding, synaptogenesis, synaptic and
homeostatic plasticity will be discussed. The second part will
focus on the emerging ECM-dependent mechanisms associated with CNS
injury, epilepsy, neurodegenerative and neuropsychiatric diseases.
For further development of neural ECM field, a very important
contribution is the third part of the book, which is devoted to
neural ECM-targeting tools and therapeutics. The concluding fourth
part will highlight advances in development of artificial ECM and
ECM-based systems suitable for multisite recording and stimulation
of neural cells.
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