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The state of the art in Biopharmaceutics, Pharmacokinetics, and
Pharmacodynamics Modeling is presented in this new second edition
book. It shows how advanced physical and mathematical methods can
expand classical models in order to cover heterogeneous
drug-biological processes and therapeutic effects in the body. The
book is divided into four parts; the first deals with the
fundamental principles of fractals, diffusion and nonlinear
dynamics; the second with drug dissolution, release, and
absorption; the third with epirical, compartmental, and stochastic
pharmacokinetic models, with two new chapters, one on fractional
pharmacokinetics and one on bioequivalence; and the fourth mainly
with classical and nonclassical aspects of pharmacodynamics. The
classical models that have relevance and application to these
sciences are also considered throughout. This second edition has
new information on reaction limited models of dissolution, non
binary biopharmaceutic classification system, time varying models,
and interface models. Many examples are used to illustrate the
intrinsic complexity of drug administration related phenomena in
the human, justifying the use of advanced modeling methods. This
book will appeal to graduate students and researchers in
pharmacology, pharmaceutical sciences, bioengineering, and
physiology. Reviews of the first edition: "This book presents a
novel modelling approach to biopharmaceutics, pharmacokinetics and
pharmacodynamic phenomena. This state-of-the-art volume will be
helpful to students and researchers in pharmacology,
bioengineering, and physiology. This book is a must for
pharmaceutical researchers to keep up with recent developments in
this field." (P. R. Parthasarathy, Zentralblatt MATH, Vol. 1103
(5), 2007) "These authors are the unique (or sole) contributors in
this area that are working on these questions and bring a special
expertise to the field that is now being recognized as essential to
understanding biological system and kinetic/dynamic characteristics
in drug development...This text is an essential primer for those
who would envision the incorporation of heterogeneous approaches to
systems where homogeneous approaches are not sufficient to describe
the system." (Robert R. Bies, Journal of Clinical Pharmacology,
Vol. 46, 2006)
The state of the art in Biopharmaceutics, Pharmacokinetics, and
Pharmacodynamics Modeling is presented in this new second edition
book. It shows how advanced physical and mathematical methods can
expand classical models in order to cover heterogeneous
drug-biological processes and therapeutic effects in the body. The
book is divided into four parts; the first deals with the
fundamental principles of fractals, diffusion and nonlinear
dynamics; the second with drug dissolution, release, and
absorption; the third with epirical, compartmental, and stochastic
pharmacokinetic models, with two new chapters, one on fractional
pharmacokinetics and one on bioequivalence; and the fourth mainly
with classical and nonclassical aspects of pharmacodynamics. The
classical models that have relevance and application to these
sciences are also considered throughout. This second edition has
new information on reaction limited models of dissolution, non
binary biopharmaceutic classification system, time varying models,
and interface models. Many examples are used to illustrate the
intrinsic complexity of drug administration related phenomena in
the human, justifying the use of advanced modeling methods. This
book will appeal to graduate students and researchers in
pharmacology, pharmaceutical sciences, bioengineering, and
physiology. Reviews of the first edition: "This book presents a
novel modelling approach to biopharmaceutics, pharmacokinetics and
pharmacodynamic phenomena. This state-of-the-art volume will be
helpful to students and researchers in pharmacology,
bioengineering, and physiology. This book is a must for
pharmaceutical researchers to keep up with recent developments in
this field." (P. R. Parthasarathy, Zentralblatt MATH, Vol. 1103
(5), 2007) "These authors are the unique (or sole) contributors in
this area that are working on these questions and bring a special
expertise to the field that is now being recognized as essential to
understanding biological system and kinetic/dynamic characteristics
in drug development...This text is an essential primer for those
who would envision the incorporation of heterogeneous approaches to
systems where homogeneous approaches are not sufficient to describe
the system." (Robert R. Bies, Journal of Clinical Pharmacology,
Vol. 46, 2006)
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