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Over the last several decades breast cancer management has made
great strides in the improvement of oncologic treatment outcomes,
particularly so in patients with early stage disease. While
wide-spread access to screening resulting in early detection is
undoubtedly to be credited for this trend, at the same time, the
management of breast cancer has evolved to be an intricate
multidisciplinary collaboration between breast imagers, surgeons,
medical oncologists and radiation oncologist. As a result, with
better mutual understanding of multidisplinary goals and
challenges, the treatment strategies have become more
individualized, with a great emphasis being placed on the intrinsic
disease biology. Furthermore, the indications for neoadjuvant
systemic therapy have significantly broadened, with a substantial
number of patients with early stage breast cancer being able to
take advantage of this strategy to decrease the extent of breast
surgery they would undergo at its completion. As such, the
management of the axilla in these patients has presented with new
challenges as well as with new opportunities to scale down on the
extent of local therapy and, consequently, its toxicity. This text
will provide a comprehensive, state-of-the art review of this
field, and will serve as a valuable resource for clinicians
(surgeons, medical oncologists, radiation oncologists) and
researchers with an interest in breast cancer. The book will review
novel and evoling strategies in neoadjuvant systemic therapy forn
early stage breast cancer, provide new perspectives about
appropriate axillary imaging in anticipation of neoadjuvant
systemic therapy, and describe new data on innovative surgical
techniques and Radiation Oncology concepts designed to deescalate
the extent and toxicity of local therapy while insuring oncologic
safety. Several landmark clinical trials have been published in the
last few years and will be placed in context with respect to
current management. Integration of novel diagnostic and
interventional breast imaging, local therapy (surgery and
radiation) with contemporary systemic therapy will also be
discussed. This text will serve as a very useful resource for
physicians and researchers dealing with, and interested in, this
challenging field. It will provide a concise yet comprehensive
summary of the current status of the field that will help guide
patient management and stimulate investigative efforts. All
chapters will be written by experts in their fields and will
include the most up to date scientific and clinical information.
This first of two volumes provides and in-depth account of breast
disease characteristics, imaging and diagnosis. Covering from
breast anatomy and tumor biology to benign and malignant lesions
this is an indispensable companion for breast specialists, medical
oncologists, radiologists and pathologists. The book is organised
in themed parts exploring topics such as epidemiology, risk
factors, genetic biomarkers, pathological evaluation of tumors and
biopsy techniques. With a high number of colored illustrations and
edited by highly experienced clinicians, this work enables readers
to gain an interdisciplinary perspective on breast diseases.
Contributions from an international team of experts present
invaluable insight into pathological and epidemiological aspects of
breast disease. Covering both theoretical and practical aspects of
breast cancer this is a highly informative and carefully presented
book which will appeal to an international audience of breast
cancer practitioners.
Over the last several decades breast cancer management has made
great strides in the improvement of oncologic treatment outcomes,
particularly so in patients with early stage disease. While
wide-spread access to screening resulting in early detection is
undoubtedly to be credited for this trend, at the same time, the
management of breast cancer has evolved to be an intricate
multidisciplinary collaboration between breast imagers, surgeons,
medical oncologists and radiation oncologist. As a result, with
better mutual understanding of multidisplinary goals and
challenges, the treatment strategies have become more
individualized, with a great emphasis being placed on the intrinsic
disease biology. Furthermore, the indications for neoadjuvant
systemic therapy have significantly broadened, with a substantial
number of patients with early stage breast cancer being able to
take advantage of this strategy to decrease the extent of breast
surgery they would undergo at its completion. As such, the
management of the axilla in these patients has presented with new
challenges as well as with new opportunities to scale down on the
extent of local therapy and, consequently, its toxicity. This text
will provide a comprehensive, state-of-the art review of this
field, and will serve as a valuable resource for clinicians
(surgeons, medical oncologists, radiation oncologists) and
researchers with an interest in breast cancer. The book will review
novel and evoling strategies in neoadjuvant systemic therapy forn
early stage breast cancer, provide new perspectives about
appropriate axillary imaging in anticipation of neoadjuvant
systemic therapy, and describe new data on innovative surgical
techniques and Radiation Oncology concepts designed to deescalate
the extent and toxicity of local therapy while insuring oncologic
safety. Several landmark clinical trials have been published in the
last few years and will be placed in context with respect to
current management. Integration of novel diagnostic and
interventional breast imaging, local therapy (surgery and
radiation) with contemporary systemic therapy will also be
discussed. This text will serve as a very useful resource for
physicians and researchers dealing with, and interested in, this
challenging field. It will provide a concise yet comprehensive
summary of the current status of the field that will help guide
patient management and stimulate investigative efforts. All
chapters will be written by experts in their fields and will
include the most up to date scientific and clinical information.
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