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One of the main reasons that this edition was undertaken is that
for some years there has been no single, up-to-date book containing
extensive information on benign and reactive lymphoid conditions.
Although malignant processes garner the majority of attention, it
is the benign processes that have an underlying complexity that is
often an illustration of the delicate interplay of many components
of the active immune system. In diagnosing the pathologic specimen,
a basic approach is: 1. To determine if the process is benign or
malignant. 2. If malignant, to characterise the origin of the
malignancy. 3. To subclassify or identify the process. In some
cases, the first part-the question of benign versus
malignant-cannot be resolved by histomorphologic evaluation alone.
The second part of the approach has become considerably easier with
the advent of immunophenotypic analysis. The final issue, that of
identification of the pathologic process, may be of greater or
lesser importance, depending on the clinical situation. If an exact
diagnosis can be made it can have several benefits. In the case of
neoplastic processes, it may indicate the type of treatment and the
prognosis. In benign processes, there are other important benefits
as well. Although some therapies may be instituted in benign
conditions, often simply naming a thing can have great benefit to
the patient. It is important to realise that even in the case of a
purely reactive process, finding a name, a category, a
classification, can provide real peace of mind to the patient. As
the American Journal of Clinical Pathology declares, "The hundreds
of images are the greatest asset of this book. There are
extraordinary renditions of such exquisite classic (yet rarely
illustrated) entities: `sago' and `lardaceous' spleens, `lollipop'
and `explosive' lymphoid follicles, multinucleated measles cells
and hyperplastic mesothelial inclusions, and sundry mystifying
diseases, including those known eponymously: Kawasaki, Kikuchi, and
Kimura." For pathologists and hematopathologists specifically, the
authors have created a book that will serve for years as a useful
guide to the multifaceted world of benign and reactive lesions of
the lymphoid system.
This book provides a highly illustrated and comprehensive account
of the diseases of the human bone marrow. It will help experienced
clinicians and those in training to answer the practical diagnostic
questions that arise during the routine analysis of bone marrow
core biopsy specimens. Throughout the text, histologic
interpretation is integrated with clinical and laboratory findings.
Emphasis is placed on the evaluation of peripheral blood, aspirate
smear, clot section and core biopsy, as well as ancillary
techniques including flow cytometry and immunohistochemistry in the
diagnosis of hematologic disorders of the marrow. The text is
illustrated with numerous color figures, charts and tables, and
descriptions of real case situations using the most up-to-date
classification systems. Illustrated Pathology of Bone Marrow should
be read by all pathologists, hematologists and laboratory
technicians involved in the analysis of bone marrow specimens.
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