The world's leading reference in hematopathology returns with this completely updated second edition. Authored by international experts in the field, it covers a broad range of hematologic disorders -- both benign and malignant -- with information on the pathogenesis, clinical and pathologic diagnosis, and treatment for each. Comprehensive in scope, it's a must-have resource for both residents and practicing pathologists alike. Authored by the chief architects of the WHO classification in neoplasms of hematopoietic and lymphoid tissue. Covers the newest diagnostic techniques, including molecular, immunohistochemical, and genetic studies. Confirm or challenge your diagnostic interpretations by comparing specimens to over 1,000 high-quality color images. Boasts detailed, practical advice from world leaders in hematopathology. Places an emphasis on pathologic diagnoses, including molecular and genetic testing. Updated with the most current WHO classifications of hematologic disease, including lymphoma and leukemia and peripheral T-cell lymphomas. Covers hot topics in hematopathology, such as the latest genetic insights into lymphoma and leukemia; the new nomenclature for myelodysplastic syndromes; new developments on the subject of Grey zone lymphoma; and much more. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, and references from the book on a variety of devices. There's also a downloadable image bank, and Virtual Microscope Slides are featured in several chapters. Give your clinicians the best guidance with this comprehensive reference in hematopathology.

One of the main reasons that this edition was undertaken is that for some years there has been no single, up-to-date book containing extensive information on benign and reactive lymphoid conditions. Although malignant processes garner the majority of attention, it is the benign processes that have an underlying complexity that is often an illustration of the delicate interplay of many components of the active immune system. In diagnosing the pathologic specimen, a basic approach is: 1. To determine if the process is benign or malignant. 2. If malignant, to characterise the origin of the malignancy. 3. To subclassify or identify the process. In some cases, the first part-the question of benign versus malignant-cannot be resolved by histomorphologic evaluation alone. The second part of the approach has become considerably easier with the advent of immunophenotypic analysis. The final issue, that of identification of the pathologic process, may be of greater or lesser importance, depending on the clinical situation. If an exact diagnosis can be made it can have several benefits. In the case of neoplastic processes, it may indicate the type of treatment and the prognosis. In benign processes, there are other important benefits as well. Although some therapies may be instituted in benign conditions, often simply naming a thing can have great benefit to the patient. It is important to realise that even in the case of a purely reactive process, finding a name, a category, a classification, can provide real peace of mind to the patient. As the American Journal of Clinical Pathology declares, "The hundreds of images are the greatest asset of this book. There are extraordinary renditions of such exquisite classic (yet rarely illustrated) entities: `sago' and `lardaceous' spleens, `lollipop' and `explosive' lymphoid follicles, multinucleated measles cells and hyperplastic mesothelial inclusions, and sundry mystifying diseases, including those known eponymously: Kawasaki, Kikuchi, and Kimura." For pathologists and hematopathologists specifically, the authors have created a book that will serve for years as a useful guide to the multifaceted world of benign and reactive lesions of the lymphoid system.