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Includes a guide for troubleshooting of film-coated products Lists
trademarked ingredients and equipment for film coating Presents a
checklist for a QC coating-defect reporting program This book is a
complete, authoritative resource on the coating of tablets,
capsules, and other solid dosage forms of therapeutic agents.
Fourteen authors cover the industry's technologies. The book begins
with a full discussion of the primary processes -- sugar coating,
film coating, and microencapsulation -- as well as the rationale
for coating, methodologies, formulations, processing methods, and
equipment and cleaning. Then it explores automation of the coating
process, including hardware and software requirements. Finally, the
book examines major stability and quality control issues.
Regulations underlie all discussions.
This book is a complete, authoritative resource on the coating of
tablets, capsules, and other solid dosage forms of therapeutic
agents. Fourteen authors cover the industry's technologies. The
book begins with a full discussion of the primary processes --
sugar coating, film coating, and microencapsulation -- as well as
the rationale for coating, methodologies, formulations, processing
methods, and equipment and cleaning. Then it explores automation of
the coating process, including hardware and software requirements.
Finally, the book examines major stability and quality control
issues. Regulations underlie all discussions.
The objective of the study was to develop a controlled release
dosage form of insulin, which can provide basal concentrations of
insulin in diabetic rats for 1 to 2 weeks after a single
subcutaneous injection. A biodegradable injectable drug delivery
gel was prepared by dissolving a biodegradable polymer,
polylactic-co-glycolic acid (PLGA), in biocompatible
plasticizer(s), triethyl citrate (TEe and/or acetyl triethyl
citrate (ATEe. Insulin or modified insulin was then loaded into the
blank gel to form insulin or modified insulin suspension in the
polymer solution. After the insulin-loaded gel was injected
subcutaneously, the insulin or modified insulin was released slowly
from the depot by a combination of drug diffusion and erosion of
the polymer. The formulation prepared with 5% PLGA, ATEu TEC (3:1)
and 4% modified insulin glargine was able to suppress the blood
glucose concentrations of the ZDF rats significantly for 10 days
after a single subcutaneous injection. The addition of zinc sulfate
to the formulations prepared with purified insulin glargine
particles further slowed down the drop in blood glucose
concentrations.
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