Recent advances in understanding of fundamental immunology have created new insights into the dynamic interactions between tumors and the immune system. This includes new understanding of T- and B-cell interaction, immune inhibitory mechanisms including the biology of T regulatory cells, myeloid suppressor cells, and dendritic cell subsets. Enhanced understanding of mechanisms underlying T-cell anergy such as arginine deprivation, immunosuppressive cytokines, defective innate and interferon response pathways, and NKG2D downregulation have all provided new insight into suppression of anti-tumor immunity and tumor evasion. In addition to emerging understanding of tumor evasion, new immune targets such as CTLA4 blockade, NK stimulatory receptors, manipulation of the antigen processing and presentation, cytokine and costimulatory responses all provide new possibilities for enhancing anti-tumor immunity even in tumors previously felt to be resistant to immune attack. Several of these strategies have already been realized in the clinic. The volume will explore evolving paradigms in antigen presentation, dendritic cell biology, the innate response and immunosuppressive mechanisms, and emerging strategies for manipulation of the immune system for therapeutic benefit that have realized success in neuroblastoma, leukemia, melanoma, lung cancer, and allogeneic transplantation. Early successes as well as failures will be highlighted to provide a snapshot of the state of clinical immunotherapy with an eye to future possibilities such as combination therapies, adoptive T-cell transfer, and the retargeting of immune cells via T-cell receptor engineering.

Recent advances in understanding of fundamental immunology have created new insights into the dynamic interactions between tumors and the immune system. This includes new understanding of T- and B-cell interaction, immune inhibitory mechanisms including the biology of T regulatory cells, myeloid suppressor cells, and dendritic cell subsets.

Enhanced understanding of mechanisms underlying T-cell anergy such as arginine deprivation, immunosuppressive cytokines, defective innate and interferon response pathways, and NKG2D downregulation have all provided new insight into suppression of anti-tumor immunity and tumor evasion.

In addition to emerging understanding of tumor evasion, new immune targets such as CTLA4 blockade, NK stimulatory receptors, manipulation of the antigen processing and presentation, cytokine and costimulatory responses all provide new possibilities for enhancing anti-tumor immunity even in tumors previously felt to be resistant to immune attack. Several of these strategies have already been realized in the clinic. The volume will explore evolving paradigms in antigen presentation, dendritic cell biology, the innate response and immunosuppressive mechanisms, and emerging strategies for manipulation of the immune system for therapeutic benefit that have realized success in neuroblastoma, leukemia, melanoma, lung cancer, and allogeneic transplantation. Early successes as well as failures will be highlighted to provide a snapshot of the state of clinical immunotherapy with an eye to future possibilities such as combination therapies, adoptive T-cell transfer, and the retargeting of immune cells via T-cell receptor engineering.

El procedimiento de transformacion de las sociedades mercantiles en Cuba, posee los conceptos y principios que conforman la teoria y los procedimientos que a nivel internacional existen para regular su tratamiento juridico, asi como regulaciones juridicas bien concebidas a traves de leyes especiales o en otras normativas donde es regulada, es entonces que acorde a las circunstancias actuales en que Cuba, insertada en procesos de integracion con paises de Iberoamerica, tiene necesidad de la inclusion en la legislacion en relacion al procedimiento de transformacion de las sociedades mercantiles. El trabajo tiene como objetivo fundamental diagnosticar el estado actual de la legislacion cubana en relacion a las normas que regulen el procedimiento para la transformacion de las sociedades mercantiles, en aras de garantizar la eficacia de la economia cubana. La investigacion presenta como resultado un diagnostico del estado actual de la legislacion cubana en relacion a las normas que regulan el procedimiento de transformacion de las sociedades mercantiles y la novedad cientifica radica, en recomendaciones para el perfeccionamiento de la normativa juridica en esta materia."

Es el latin la lengua madre de todas las lenguas latinas. Fue en latin en el idioma que hablaron pensaron y escribieron los principales jurisconsultos, historiadores y poetas de la Roma antigua. El Derecho Romano es la base tecnica de nuestro sistema de derecho; sus instituciones, aun hoy en dia, nos asombran. Hay documentos que llevan nombres en latin, abogados que dicen frases en latin y derechos que se mencionan en latin. Roma fue el mas grande imperio de su epoca. Pero no solo se limito a someter pueblos y aumentar sus riquezas; Roma fue capaz de dar y recibir. Su politica expansionista les dio el poder, su ambicion les dio el querer, mas su increible genio politico-social le dio la capacidad suficiente para comprender que no solo por la fuerza, podia someter pueblos y que su derecho, el viejo derecho quiritario, no era ni suficiente. La Ley de las Doce Tablas, el Derecho Pretoriano, el Corpus Iuris Civilis, entre otros, tuvieron en el latin su lengua de expresion y a traves de ella se desprendieron los distintos derechos positivos; por lo que muchas voces latinas son de uso casi diario para conocer, interpretar, y aplicar normas juridicas o textos de consulta."