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Actin Polymerization in Apicomplexan - A Structural, Functional and Evolutionary Analysis (Hardcover, 1st ed. 2019): Avinash... Actin Polymerization in Apicomplexan - A Structural, Functional and Evolutionary Analysis (Hardcover, 1st ed. 2019)
Avinash Kale
R2,873 Discovery Miles 28 730 Ships in 10 - 15 working days

This book discusses in detail the structural, evolutionary and functional role of actin and its regulatory proteins in gliding motility in apicomplexan organisms, a unique phenomenon found in actin-myosin cytoskeletal elements. The book also explores the potential of different actin regulators, namely formin, profilin, actin depolymerization factor (ADF), capping proteins (CP and CP ), cyclase-associated protein (CAP) and coronin 13-24 as potential drug targets against malaria. As the chief components of the gliding motor, the actin-regulator proteins are characterized by unique features that make them promising targets for structure-based drug design. Lastly, the book proposes a mathematical model, based on kinetic data mining, to help understand the most vital regulators for actin polymerization dynamics.

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