The topic of this book, Collectins, is a family of proteins whose major function is in innate immunity, where Collectins act as pattern recognition receptors (PRRs). In general they recognize targets such as microbial surfaces and apoptotic cells, and once bound to a target, Collectins promote the clearance of microorganisms and damaged host tissue. New cell-surface proteins and glycoproteins, which act as Collectin receptors, are currently being identified. Some Collectins, particularly MBL, activate the complement system, which enhances the ability of antibodies to fight pathogens, via three MBL-associated proteases, the MASPs. Additionally, recent research has begun to show wider-ranging activities of Collectins, such as: * Their role in metabolism, and therefore their involvement in lifestyle diseases such as obesity and cardiovascular disease. * Their ability to modulate the adaptive immune response, as well as to recognize and trigger apoptosis of cancer cells, which makes them effective in the annihilation of cancer cells with multiple mutations. * The regulation of their expression by gonadal steroid hormones implicates them with critical roles in both male and female fertility. * Altered levels of Collectins have been associated with various autoimmune diseases. This book brings together current knowledge of the structure, functions and biological activities of Collectins, to describe their integral role in human health.

Domestic Violence Laws in the United States and India is a comparative study of the domestic violence laws in India and the United States, seeking to illuminate the critical issues of intimate partner violence through the lenses of these two societies.

Metric fixed point theory encompasses the branch of fixed point theory which metric conditions on the underlying space and/or on the mappings play a fundamental role. In some sense the theory is a far-reaching outgrowth of Banach's contraction mapping principle. A natural extension of the study of contractions is the limiting case when the Lipschitz constant is allowed to equal one. Such mappings are called nonexpansive. Nonexpansive mappings arise in a variety of natural ways, for example in the study of holomorphic mappings and hyperconvex metric spaces. Because most of the spaces studied in analysis share many algebraic and topological properties as well as metric properties, there is no clear line separating metric fixed point theory from the topological or set-theoretic branch of the theory. Also, because of its metric underpinnings, metric fixed point theory has provided the motivation for the study of many geometric properties of Banach spaces. The contents of this Handbook reflect all of these facts. The purpose of the Handbook is to provide a primary resource for anyone interested in fixed point theory with a metric flavor. The goal is to provide information for those wishing to find results that might apply to their own work and for those wishing to obtain a deeper understanding of the theory. The book should be of interest to a wide range of researchers in mathematical analysis as well as to those whose primary interest is the study of fixed point theory and the underlying spaces. The level of exposition is directed to a wide audience, including students and established researchers.

The complement system is a group of proteins which plays a major role in the processing and removal of microorganisms and tissue breakdown products from the circulation and extracellular spaces. The system is activated by a wide range of targets, and activation leads to the production of opsonins, chemotaxis of granulocytes, cell lysis and other biological activities. Inappropriate overactivation of the system contributes to inflammatory tissue damage in the host, while inadequate activation leads to accumulation of immune complexes and other debris in the circulation, and susceptibility to infection. The biology and biochemistry of the system is now adequately understood, and attempts can be made to manipulate the activation and activities of the system for potential therapeutic purposes. The reviews in this volume summarise what is known of the ways in which the complement system can be activated, by interaction with antibodies, microorganisms, cell debris, and complex carbohydrates and how the activities and activation of the system have been modified, accidentally or by design, in vitro or in vivo by drugs, venoms, particulate carbohydrates, specific antibodies, synthetic peptides and other reagents.

This book explores the potential of multi-functional carbon nanotubes for biomedical applications. It combines contributions from chemistry, physics, biology, engineering, and medicine. The complete overview of the state-of-the-art addresses different synthesis and biofunctionalisation routes and shows the structural and magnetic properties of nanotubes relevant to biomedical applications. Particular emphasis is put on the interaction of carbon nanotubes with biological environments, i.e. toxicity, biocompatibility, cellular uptake, intracellular distribution, interaction with the immune system and environmental impact. The insertion of NMR-active substances allows diagnostic usage as markers and sensors, e.g. for imaging and contactless local temperature sensing. The potential of nanotubes for therapeutic applications is highlighted by studies on chemotherapeutic drug filling and release, targeting and magnetic hyperthermia studies for anti-cancer treatment at the cellular level.

Immunity studies in sharks over the past three decades have produced some remarkable discoveries. If one message rings true, it is that alternative animal model systems, such as sharks and their relatives, have contributed very substantially to a better understanding of the development evolution of our own immune system. Immunobiology of the Shark describes the cellular, genetic, and molecular specifics of immune systems in sharks. Diverse approaches were employed to study the immunobiology of the shark from basic microscopic observations to detailed genome annotation. The book also raises a series of fascinating questions, which can be addressed experimentally using today's technology. This book will be a valuable resource for mainstream immunologists, comparative immunologists, geneticists, ecologists, evolutionary biologists, and investigators engaged in shark research. The book also aims to illustrate the magnificence of these animals as model systems and underscores the importance of their study to further understand their complex, and often enigmatic, biology.

This book explores the potential of multi-functional carbon nanotubes for biomedical applications. It combines contributions from chemistry, physics, biology, engineering, and medicine. The complete overview of the state-of-the-art addresses different synthesis and biofunctionalisation routes and shows the structural and magnetic properties of nanotubes relevant to biomedical applications. Particular emphasis is put on the interaction of carbon nanotubes with biological environments, i.e. toxicity, biocompatibility, cellular uptake, intracellular distribution, interaction with the immune system and environmental impact. The insertion of NMR-active substances allows diagnostic usage as markers and sensors, e.g. for imaging and contactless local temperature sensing. The potential of nanotubes for therapeutic applications is highlighted by studies on chemotherapeutic drug filling and release, targeting and magnetic hyperthermia studies for anti-cancer treatment at the cellular level.

The complement system is a group of proteins which plays a major role in the processing and removal of microorganisms and tissue breakdown products from the circulation and extracellular spaces. The system is activated by a wide range of targets, and activation leads to the production of opsonins, chemotaxis of granulocytes, cell lysis and other biological activities. Inappropriate overactivation of the system contributes to inflammatory tissue damage in the host, while inadequate activation leads to accumulation of immune complexes and other debris in the circulation, and susceptibility to infection. The biology and biochemistry of the system is now adequately understood, and attempts can be made to manipulate the activation and activities of the system for potential therapeutic purposes. The reviews in this volume summarise what is known of the ways in which the complement system can be activated, by interaction with antibodies, microorganisms, cell debris, and complex carbohydrates and how the activities and activation of the system have been modified, accidentally or by design, in vitro or in vivo by drugs, venoms, particulate carbohydrates, specific antibodies, synthetic peptides and other reagents.

Metric fixed point theory encompasses the branch of fixed point theory which metric conditions on the underlying space and/or on the mappings play a fundamental role. In some sense the theory is a far-reaching outgrowth of Banach's contraction mapping principle. A natural extension of the study of contractions is the limiting case when the Lipschitz constant is allowed to equal one. Such mappings are called nonexpansive. Nonexpansive mappings arise in a variety of natural ways, for example in the study of holomorphic mappings and hyperconvex metric spaces. Because most of the spaces studied in analysis share many algebraic and topological properties as well as metric properties, there is no clear line separating metric fixed point theory from the topological or set-theoretic branch of the theory. Also, because of its metric underpinnings, metric fixed point theory has provided the motivation for the study of many geometric properties of Banach spaces. The contents of this Handbook reflect all of these facts. The purpose of the Handbook is to provide a primary resource for anyone interested in fixed point theory with a metric flavor. The goal is to provide information for those wishing to find results that might apply to their own work and for those wishing to obtain a deeper understanding of the theory. The book should be of interest to a wide range of researchers in mathematical analysis as well as to those whose primary interest is the study of fixed point theory and the underlying spaces. The level of exposition is directed to a wide audience, including students and established researchers.

In Scripture, parents are instructed to teach their kids how to love God and saturate their home with the gospel (Deut 4:9, 6:1-7; Eph 6:104). Husbands and wives are commanded to mirror Jesus in their marriages (Eph 5:22-33). We understand these commands in light of the gospel-in light of Jesus Christ (2 Cor 4:6). Jesus is the hero of our families. That's what A Household Gospel is about. It's ordinary means rooted in an extraordinary gospel. It's about starting the great commission in our homes. It's about rehearsing the gospel story when we sit to eat, lay down to sleep, rise up in the morning, and everywhere in between.

Immunity studies in sharks over the past three decades have produced some remarkable discoveries. If one message rings true, it is that alternative animal model systems, such as sharks and their relatives, have contributed very substantially to a better understanding of the development evolution of our own immune system. Immunobiology of the Shark describes the cellular, genetic, and molecular specifics of immune systems in sharks. Diverse approaches were employed to study the immunobiology of the shark from basic microscopic observations to detailed genome annotation. The book also raises a series of fascinating questions, which can be addressed experimentally using today's technology. This book will be a valuable resource for mainstream immunologists, comparative immunologists, geneticists, ecologists, evolutionary biologists, and investigators engaged in shark research. The book also aims to illustrate the magnificence of these animals as model systems and underscores the importance of their study to further understand their complex, and often enigmatic, biology.