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Acetylcholinesterase plays a key role in cholinergic transnnSSlOn.
By rapid hydrolysis of the neurotransmitter acetylcholine the
enzyme terminates the chemical impluse, thereby allowing rapid
repetitive responses. Inhibitors of cholinesterases have important
applications in agriculture - pest control, and in medicine -
treatment of various disorders such as myasthenia gravis, glaucoma
and management of Alzheimer's disease. These are some of the
reasons for the special attraction of scientists from multiple
disciplines such as neurobiology, pharmacology, chemistry,
biochemistry, molecular biology and biotechnology to cholinesterase
research. We have been fortunate to organize the 36th OHOLO
conference on Multidisciplinary Approaches to Cholinesterase
Functions at a time when this field of research is bursting with
new concepts and ideas, brought about by the recent structural
resolution of the catalytic subunit of acetylcholinesterase and by
application of methodologies related to molecular genetics and
protein engineering. This volume summarizes most of the important
advances resulting from these developments as reflected in the
OHOLO meeting.
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