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Aneuploidy - the greatest genetic affliction of man - has its
origin in manycellular processes. Its forerunner, chromosome
non-disjunction, can result from malfunction of one of many
processes involved in faithful segregation of chromosomes during
mitosis or meiosis. Experts on chromosome biology, centromere,
kinetochore, microtubules, spindle apparatus, biochemistry of
mitosis and meiosis, developmental biology, and environmental
mutagenesis discuss basic and applied aspects of how chromosomes
malsegregate and how aneuplody originates. The most recent
techniques employed to study chromosome segregation and also
methods to determine aneugenic chemicals are described.
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