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This book summarizes the recent advances for the understanding of
circadian clock system in the regulation of drug metabolism and
pharmacokinetics. Basic knowledge in the field of circadian clock
and pharmacokinetics are systemically introduced to make it easier
for readers to understand the entire book's contents. The rhythmic
expression of DMEs (drug-metabolizing enzymes) and transporters are
summarized, and the underlying mechanisms thereof (i.e., regulation
by circadian oscillators) are discussed. Typically, evidence for
the DME- and transporter-mediated chronopharmacokinetics,
chronotoxicity and chronoefficacy are highlighted in this book.
This book summarizes the recent advances for the understanding of
circadian clock system in the regulation of drug metabolism and
pharmacokinetics. Basic knowledge in the field of circadian clock
and pharmacokinetics are systemically introduced to make it easier
for readers to understand the entire book's contents. The rhythmic
expression of DMEs (drug-metabolizing enzymes) and transporters are
summarized, and the underlying mechanisms thereof (i.e., regulation
by circadian oscillators) are discussed. Typically, evidence for
the DME- and transporter-mediated chronopharmacokinetics,
chronotoxicity and chronoefficacy are highlighted in this book.
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