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This book presents a state-of-the-art report on recent advances
concerning Ganoderma and where the field is going. Although some
older work is also cited, the main focus is on advances made over
the past 20 years in the pharmacology and clinical applications of
Ganoderma. Ganoderma lucidum (Lingzhi) has been used as a
traditional medicine in Asian countries to maintain health and to
treat diseases for more than two thousand years. Recently, its
value has been demonstrated in preventing and treating certain
diseases, such as tumors, liver disorders, renal injury,
hypercholesterolemia, obesity, cerebral ischemia reperfusion,
bronchitis etc. In addition, laboratory and clinical studies have
confirmed that the chemical components of Ganoderma, such as
Ganoderma lucidum polysaccharide peptides and triterpenes isolated
from the fruiting body of Ganoderma lucidum, produce diverse
pharmacological effects. Ganoderma and its components play an
important part in antioxidant stress, radical-scavenging,
immunomodulation, and intracellular signaling regulation, and
accordingly warrant further study. This book systematically reviews
the latest advances in our understanding of pharmacology and
clinical applications of Ganoderma, and offers researchers and
graduate students valuable new insights into the pharmacology and
clinical applications of Ganoderma and related products.
The mechanisms and physiological functions of urea transporters
across biological membranes are subjects of long-standing
interests. Although urea represents roughly 40% of all urinary
solutes in normal human urine, the handling of urea in the tissues
has been largely neglected in the past and few clinical or
experimental studies now report data on urea. Most recent
physiological text books include chapters on water and electrolyte
physiology but no chapter on urea. Our aim in writing this book is
to stimulate further research in new directions by providing novel
and provocative insights into the further mechanisms and
physiological significance of urea metabolism and transport in
mammals. This book offers a state-of-the-art report on recent
discoveries concerning urea transport and where the field is going.
It mainly focuses on advances made over the past 20 years on the
biophysics, genetics, protein structure, molecular biology,
physiology, pathophysiology and pharmacology of urea transport in
mammalian cell membranes. It will help graduate students and
researchers to get an overall picture of mammalian urea
transporters and may also yield benefits for pharmaceutical
companies with regard to drug discovery based on the urea
transporter. Baoxue Yang is a professor and vice chairman of the
Department of Pharmacology, Peking University. He is also an
adjunct professor of Jilin University and a visiting professor of
Northeast Normal University. Prof. Yang has been researching urea
transporters for nearly 20 years and has published more than 70
original research articles in this field.
The mechanisms and physiological functions of urea transporters
across biological membranes are subjects of long-standing
interests. Although urea represents roughly 40% of all urinary
solutes in normal human urine, the handling of urea in the tissues
has been largely neglected in the past and few clinical or
experimental studies now report data on urea. Most recent
physiological text books include chapters on water and electrolyte
physiology but no chapter on urea. Our aim in writing this book is
to stimulate further research in new directions by providing novel
and provocative insights into the further mechanisms and
physiological significance of urea metabolism and transport in
mammals. This book offers a state-of-the-art report on recent
discoveries concerning urea transport and where the field is going.
It mainly focuses on advances made over the past 20 years on the
biophysics, genetics, protein structure, molecular biology,
physiology, pathophysiology and pharmacology of urea transport in
mammalian cell membranes. It will help graduate students and
researchers to get an overall picture of mammalian urea
transporters and may also yield benefits for pharmaceutical
companies with regard to drug discovery based on the urea
transporter. Baoxue Yang is a professor and vice chairman of the
Department of Pharmacology, Peking University. He is also an
adjunct professor of Jilin University and a visiting professor of
Northeast Normal University. Prof. Yang has been researching urea
transporters for nearly 20 years and has published more than 70
original research articles in this field.
This book provides a state-of-the-art report on our current
understanding of aquaporins and the future direction of the field.
Aquaporins (AQPs) are a group of water-channel proteins that are
specifically permeable to water and other small molecules, such as
glycerol and urea. To date thirteen water-channel proteins (AQP0 -
AQP12) have been cloned and the mechanisms and physiological
functions of water transport across biological membranes have long
been the subject of interest. Recent advances in the molecular
biology and physiology of water transport have yielded new insights
into how and why water moves across cell membranes, and studies on
aquaporin knockout mouse models suggest that aquaporins are
involved in the development of some diseases and they may be useful
targets of research into selective-inhibitor drugs. By focusing on
the advances made over the last 30 years in the biophysics,
genetics, protein structure, molecular biology, physiology,
pathophysiology and pharmacology of aquaporins in mammalian cell
membranes, this book provides novel insights into further
mechanisms and the physiological significance of water and some
small molecule transport in mammals in order to stimulate further
research in new directions. In the second version, fourteen
chapters will be updated base on the most recent research articles.
Ten new chapters will be added.
This book presents a state-of-the-art report on recent advances
concerning Ganoderma and where the field is going. Although some
older work is also cited, the main focus is on advances made over
the past 20 years in the pharmacology and clinical applications of
Ganoderma. Ganoderma lucidum (Lingzhi) has been used as a
traditional medicine in Asian countries to maintain health and to
treat diseases for more than two thousand years. Recently, its
value has been demonstrated in preventing and treating certain
diseases, such as tumors, liver disorders, renal injury,
hypercholesterolemia, obesity, cerebral ischemia reperfusion,
bronchitis etc. In addition, laboratory and clinical studies have
confirmed that the chemical components of Ganoderma, such as
Ganoderma lucidum polysaccharide peptides and triterpenes isolated
from the fruiting body of Ganoderma lucidum, produce diverse
pharmacological effects. Ganoderma and its components play an
important part in antioxidant stress, radical-scavenging,
immunomodulation, and intracellular signaling regulation, and
accordingly warrant further study. This book systematically reviews
the latest advances in our understanding of pharmacology and
clinical applications of Ganoderma, and offers researchers and
graduate students valuable new insights into the pharmacology and
clinical applications of Ganoderma and related products.
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