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Highlighting latest advances in genetics and biochemistry, the
completely revised Third Edition reviews the field from basic
science, clinical, epidemiological, and regulatory perspectives.
Contributions from top opinion leaders in the field bring together
developments in molecular embryology and cell biology as they apply
to problems in developmental toxicology. It covers testing of
pharmaceutical and environmental agents and interpretation of
developmental toxicology data, highlighting mathematical and
statistical techniques, as well as the effects of toxic exposure on
the functional development of various organs. The relationship
between maternal and developmental toxicology is examined, in
addition to current techniques for studying chemical disposition,
metabolism, and placental transfer. Close attention is given to the
regulatory aspects of testing and risk assessment. Pre- and
postconceptional clinical care and genetic factors in clinical
developmental toxicology are also discussed. Key topics include:
the roles of apoptosis and signal transduction pathways in normal
and abnormal development the role of epigenetic changes in
development the role of nutrition and individual susceptibility the
utility of bioinformatics global and targeted gene expression
changes
Highlighting latest advances in genetics and biochemistry, the
completely revised Third Edition reviews the field from basic
science, clinical, epidemiological, and regulatory perspectives.
Contributions from top opinion leaders in the field bring together
developments in molecular embryology and cell biology as they apply
to problems in developmental toxicology. It covers testing of
pharmaceutical and environmental agents and interpretation of
developmental toxicology data, highlighting mathematical and
statistical techniques, as well as the effects of toxic exposure on
the functional development of various organs. The relationship
between maternal and developmental toxicology is examined, in
addition to current techniques for studying chemical disposition,
metabolism, and placental transfer. Close attention is given to the
regulatory aspects of testing and risk assessment. Pre- and
postconceptional clinical care and genetic factors in clinical
developmental toxicology are also discussed. Key topics include:
the roles of apoptosis and signal transduction pathways in normal
and abnormal development the role of epigenetic changes in
development the role of nutrition and individual susceptibility the
utility of bioinformatics global and targeted gene expression
changes
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