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This practical collection examines methodologies originating from
the benefits of genome-wide approaches to studying epigenetics,
which has opened the emerging field of epigenomics. Focusing on the
areas of cancer, inflammatory and autoimmune disorders, chapters
discuss three main components of the epigenome and their role in
the regulation of gene expression and present a detailed method
section specific to studying each component, including data
analyses, troubleshooting, and feasibility in different
experimental settings. The main topics are high-throughput and
targeted methods for DNA methylation analysis, nucleosome position
mapping, studying epigenetic effects of gut microbiota, optical
imaging for detection of epigenetic aberrations in living cells,
methods for microRNA, and histone code profiling. Written for the
Methods in Pharmacology and Toxicology series, the book includes
the kind of detail and implementation advice to encourage success
in the lab. Authoritative and easily applicable, Epigenetics and
Gene Expression in Cancer, Inflammatory and Immune Diseases aims to
provide pharmacologists, molecular biologists, bioinformaticians,
and toxicologists with a vital background on epigenetics and
state-of-the-art techniques in epigenomics.
This practical collection examines methodologies originating from
the benefits of genome-wide approaches to studying epigenetics,
which has opened the emerging field of epigenomics. Focusing on the
areas of cancer, inflammatory and autoimmune disorders, chapters
discuss three main components of the epigenome and their role in
the regulation of gene expression and present a detailed method
section specific to studying each component, including data
analyses, troubleshooting, and feasibility in different
experimental settings. The main topics are high-throughput and
targeted methods for DNA methylation analysis, nucleosome position
mapping, studying epigenetic effects of gut microbiota, optical
imaging for detection of epigenetic aberrations in living cells,
methods for microRNA, and histone code profiling. Written for the
Methods in Pharmacology and Toxicology series, the book includes
the kind of detail and implementation advice to encourage success
in the lab. Authoritative and easily applicable, Epigenetics and
Gene Expression in Cancer, Inflammatory and Immune Diseases aims to
provide pharmacologists, molecular biologists, bioinformaticians,
and toxicologists with a vital background on epigenetics and
state-of-the-art techniques in epigenomics.
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