|
Showing 1 - 4 of
4 matches in All Departments
This book addresses the differentiation control of skeletal muscle
in different locations of the vertebrate body Particular attention
is paid to novel regulatory molecules and signals as well as the
heterogeneity of origin that have revealed a developmental overlap
between skeletal and cardiac muscle. Different functional muscle
groups are the product of the evolution of the vertebrate classes,
making a phylogenetic comparison worthwhile for understanding the
role of muscle stem cells and precursors in myogenesis. New
insights into the hierarchy of transcription factors, particularly
in the context of these different muscle groups have been gained
from detailed investigations of the spatio-temporal and regulatory
relationships derived from mouse and zebrafish genetics and avian
microsurgery. Importantly, epigenetic mechanisms that have surfaced
recently, in particular the role of MyomiRs, are also surveyed.
With an eye to the human patient, encouraging results have been
generated that identify parallels between embryonic myogenesis and
regenerating myofibers due to common regulatory molecules. On the
other hand, both processes differ considerably in quality and
complexity of the processes employed. Interestingly, the
heterogeneity in embryonic sources from which skeletal muscle
groups in the vertebrate including the human body take origin is
paralleled by differences in their susceptibility to particular
muscle dystrophies as well as by the characteristics of the
satellite cells involved in regeneration. The progress that has
been made in the field of muscle stem cell biology, with special
focus on the satellite cells, is outlined in this book by experts
in the field. The authors review recent insights of the
heterogeneous nature of these satellite cells regarding their gene
signatures and regeneration potential. Furthermore, an improved
understanding of muscle stem cells seems only possible when we
study the impact of the cell environment on efficient stem cell
replacement therapies for muscular dystrophies, putting
embryological findings from different vertebrate classes and stem
cell approaches into context.
This book addresses the differentiation control of skeletal muscle
in different locations of the vertebrate body Particular attention
is paid to novel regulatory molecules and signals as well as the
heterogeneity of origin that have revealed a developmental overlap
between skeletal and cardiac muscle. Different functional muscle
groups are the product of the evolution of the vertebrate classes,
making a phylogenetic comparison worthwhile for understanding the
role of muscle stem cells and precursors in myogenesis. New
insights into the hierarchy of transcription factors, particularly
in the context of these different muscle groups have been gained
from detailed investigations of the spatio-temporal and regulatory
relationships derived from mouse and zebrafish genetics and avian
microsurgery. Importantly, epigenetic mechanisms that have surfaced
recently, in particular the role of MyomiRs, are also surveyed.
With an eye to the human patient, encouraging results have been
generated that identify parallels between embryonic myogenesis and
regenerating myofibers due to common regulatory molecules. On the
other hand, both processes differ considerably in quality and
complexity of the processes employed. Interestingly, the
heterogeneity in embryonic sources from which skeletal muscle
groups in the vertebrate including the human body take origin is
paralleled by differences in their susceptibility to particular
muscle dystrophies as well as by the characteristics of the
satellite cells involved in regeneration. The progress that has
been made in the field of muscle stem cell biology, with special
focus on the satellite cells, is outlined in this book by experts
in the field. The authors review recent insights of the
heterogeneous nature of these satellite cells regarding their gene
signatures and regeneration potential. Furthermore, an improved
understanding of muscle stem cells seems only possible when we
study the impact of the cell environment on efficient stem cell
replacement therapies for muscular dystrophies, putting
embryological findings from different vertebrate classes and stem
cell approaches into context.
The development of vertebrate muscle has long been a major area of research in developmental biology. During the last decade, novel technical approaches have allowed us to unravel to a large extent the mechanisms underlying muscle formation, and myogenesis has become one of the best-understood paradigms for cellular differentiation. This book concisely summarizes our current knowledge about muscle development in vertebrates, from the determination of muscle precursors to terminal differentiation. Each chapter has been written by an expert in the field, and particular emphasis has been placed on the different developmental and molecular pathways followed by the three types of vertebrate musculature - skeletal, heart and smooth muscle.
This textbook describes the biology of different adult stem cell
types and outlines the current level of knowledge in the field. It
clearly explains the basics of hematopoietic, mesenchymal and cord
blood stem cells and also covers induced pluripotent stem cells.
Further, it includes a chapter on ethical aspects of human stem
cell research, which promotes critical thinking and responsible
handling of the material. Based on the international masters
program Molecular and Developmental Stem Cell Biology taught at
Ruhr-University Bochum and Tongji University Shanghai, the book is
a valuable source for postdocs and researchers working with stems
cells and also offers essential insights for physicians and
dentists wishing to expand their knowledge. This textbook is a
valuable complement to Concepts and Applications of Stem Cell
Biology, also published in the Learning Materials in Biosciences
textbook series.
|
You may like...
Hampstead
Diane Keaton, Brendan Gleeson, …
DVD
R66
Discovery Miles 660
Loot
Nadine Gordimer
Paperback
(2)
R398
R330
Discovery Miles 3 300
Loot
Nadine Gordimer
Paperback
(2)
R398
R330
Discovery Miles 3 300
|