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The International Symposium on Prostaglandins and Related
Compounds, first held in Vienna 1972, revisited the city after 24
years for the 10TH Symposium. For the many re searchers working in
this multi-disciplinary field it was an opportunity to exchange
their ex periences and share new data with colleagues from all
around the world. This scientific exchange was largely encouraged
by the unseasonably cold and rainy weather. For the first time,
there was quite a large attendance from the former Communist
countries. Eugene Garfield prepared a key note address delivered
during the meeting (The Sci entist 1996, 12) reviewing the
contribution of the Nobel Laureates U.S. von Euler, l.R. Vane, S.K.
Bergstrom, and B.I. Samuelsson, discussing the relevance of the
more than 40,000 pa pers in this area published since 1991.
Overall, there is still a rapidly growing interest, and in
particular a great variety of clinical applications of this family
of compounds which were dis cussed in detail during the meeting.
Beside the lectures there were 19 workshops covering nearly all the
topics of key in terest. All the speakers were invited to prepare a
manuscript which has resulted in the volume now in your hands.
Special thanks to Dr. Patrick Wong and the new publisher of this
series who helped to publish the proceedings in the usual quality
and reasonable period of time. Looking forward to seeing all of you
again in Florence in 1999, hopefully with much more sun."
Proceedings of a NATO ASI held in Erice, Italy, April 27-May 1,
1995.
The 11th international Conference on ADVANCES IN PROSTAGLANDIN AND
LEUKOTRIENE RESEARCH: BASICSCIENCEANDNEWCLlNICALApPLlCA TIONS was
held, as in the past, in Florence, Italy, on June 4-8, 2000. A
selection of lectures presented at the meeting is included in this
volume, which continues the tradition of covering both basic and
clinical aspects of prostaglandin and leukotriene research. At this
meeting particular emphasis was given to the lipid mediator
circuits of lipoxin and leukotrienes and to the expression ofthe
COX2 gene. The plenary lectures by C.N. Serhan (Boston,
Massachusetts, U.S.A.) and H.R. Herschman (Los Angeles, California,
U.S.A.) were devoted to these areas, while S. Narumiya (Kyoto,
Japan) and J.M. Drazen (Boston, Massachusetts, U.S.A.) presented
the latest advances in the fields ofprostanoid receptors and the
genetics of asthma. Specific sessions focused on vascular
physiopathology, cell differentiation and cancer, and the
cardiovascular system. Lipoxygenases were discussed in detail at
the molecular and cellular levels and attention was given to signal
transduction pathways for leukotrienes and prostanoids. K.F. Austen
(Boston, Massachusetts, U.S.A.) and T. Izumi (Tokyo, Japan)
clarified the role and regulation ofLTC synthase ofleukotriene
biosynthesis. Other important sessions 4 described regulation and
control of nitric oxide, cannabimimetic eicosanoids, and the roles
of eicosanoids in neuroscience. Applied clinical sessions devoted
to the respiratory system and inflammation, including
cyclooxygenase pathways, concluded the meeting.
Many new antileukotriene drugs are now marketed as antiasthma drugs
and represent the first new drugs in this field since the 1970s.
This book covers the steps that have led to the discovery and
development of these new drugs and offers detailed descriptions of
their clinical applications. The review chapters on the main
aspects of basic and applied leukotriene research are written by
leading specialists in the field, and the volume takes a new
approach in presenting information of particular interest to both
scientists and clinicians in the fields of asthma, inflammation and
allergic diseases.
Many new antileukotriene drugs are now marketed as antiasthma drugs
and represent the first new drugs in this field since the 1970s.
This book covers the steps that have led to the discovery and
development of these new drugs and offers detailed descriptions of
their clinical applications. The review chapters on the main
aspects of basic and applied leukotriene research are written by
leading specialists in the field, and the volume takes a new
approach in presenting information of particular interest to both
scientists and clinicians in the fields of asthma, inflammation and
allergic diseases.
The International Symposium on Prostaglandins and Related
Compounds, first held in Vienna 1972, revisited the city after 24
years for the 10TH Symposium. For the many re searchers working in
this multi-disciplinary field it was an opportunity to exchange
their ex periences and share new data with colleagues from all
around the world. This scientific exchange was largely encouraged
by the unseasonably cold and rainy weather. For the first time,
there was quite a large attendance from the former Communist
countries. Eugene Garfield prepared a key note address delivered
during the meeting (The Sci entist 1996, 12) reviewing the
contribution of the Nobel Laureates U.S. von Euler, l.R. Vane, S.K.
Bergstrom, and B.I. Samuelsson, discussing the relevance of the
more than 40,000 pa pers in this area published since 1991.
Overall, there is still a rapidly growing interest, and in
particular a great variety of clinical applications of this family
of compounds which were dis cussed in detail during the meeting.
Beside the lectures there were 19 workshops covering nearly all the
topics of key in terest. All the speakers were invited to prepare a
manuscript which has resulted in the volume now in your hands.
Special thanks to Dr. Patrick Wong and the new publisher of this
series who helped to publish the proceedings in the usual quality
and reasonable period of time. Looking forward to seeing all of you
again in Florence in 1999, hopefully with much more sun."
Proceedings of a NATO ASI held in Erice, Italy, April 27-May 1,
1995.
The 11th international Conference on ADVANCES IN PROSTAGLANDIN AND
LEUKOTRIENE RESEARCH: BASICSCIENCEANDNEWCLlNICALApPLlCA TIONS was
held, as in the past, in Florence, Italy, on June 4-8, 2000. A
selection of lectures presented at the meeting is included in this
volume, which continues the tradition of covering both basic and
clinical aspects of prostaglandin and leukotriene research. At this
meeting particular emphasis was given to the lipid mediator
circuits of lipoxin and leukotrienes and to the expression ofthe
COX2 gene. The plenary lectures by C.N. Serhan (Boston,
Massachusetts, U.S.A.) and H.R. Herschman (Los Angeles, California,
U.S.A.) were devoted to these areas, while S. Narumiya (Kyoto,
Japan) and J.M. Drazen (Boston, Massachusetts, U.S.A.) presented
the latest advances in the fields ofprostanoid receptors and the
genetics of asthma. Specific sessions focused on vascular
physiopathology, cell differentiation and cancer, and the
cardiovascular system. Lipoxygenases were discussed in detail at
the molecular and cellular levels and attention was given to signal
transduction pathways for leukotrienes and prostanoids. K.F. Austen
(Boston, Massachusetts, U.S.A.) and T. Izumi (Tokyo, Japan)
clarified the role and regulation ofLTC synthase ofleukotriene
biosynthesis. Other important sessions 4 described regulation and
control of nitric oxide, cannabimimetic eicosanoids, and the roles
of eicosanoids in neuroscience. Applied clinical sessions devoted
to the respiratory system and inflammation, including
cyclooxygenase pathways, concluded the meeting.
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