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This volume provides a collection of contemporary perspectives on
using activity-based protein profiling (ABPP) for biological
discoveries in protein science, microbiology, and immunology. A
common theme throughout is the special utility of ABPP to
interrogate protein function and small-molecule interactions on a
global scale in native biological systems. Each chapter showcases
distinct advantages of ABPP applied to diverse protein classes and
biological systems. As such, the book offers readers valuable
insights into the basic principles of ABPP technology and how to
apply this approach to biological questions ranging from the study
of post-translational modifications to targeting bacterial
effectors in host-pathogen interactions.
Human cells produce at least 30,000 different proteins. Each has a
specific function characterized by a unique sequence and native
conformation that allows it to perform that function. While
research in this post-genomic era has created a deluge of
invaluable information, the field has lacked for an authoritative
introductory text needed to inform researchers and students in all
of those fields now concerned with protein research. Introduction
to Peptides and Proteins brings together some of the most respected
researchers in protein science to present a remarkably coherent
introduction to modern peptide and protein chemistry. The first
sections of the book delve into - Basic peptide and protein science
from assembly through degradation Traditional and emerging research
methods including those used in bioinformatics and proteomics New
computational approaches and algorithms used to find patterns in
the vast data collected by sequencing projects After providing a
foundation in tools and methods, the authors closely examine six
protein families, including representative classes such as enzymes,
cell-surface receptors, antibodies, fibrous proteins, and bioactive
peptide classes. They concentrate on biochemical mechanisms and
where possible indicate therapeutic or biotechnical possibilities.
Then focusing on clinical aspects, the authors investigate
misfolding as found in prion diseases, miscleavage as found in
Alzheimer's, and mis-sequencing as found with some cancers. Drawing
from some of their own research, the authors summarize recent
achievements and emerging applications. They discuss the use of
proteins and peptides as drugs and the solid-phase synthesis
required for drug production. They also look at the use of peptides
as functional biomolecules and research tools. No longer just th
Human cells produce at least 30,000 different proteins. Each has a
specific function characterized by a unique sequence and native
conformation that allows it to perform that function. While
research in this post-genomic era has created a deluge of
invaluable information, the field has lacked for an authoritative
introductory text needed to inform researchers and students in all
of those fields now concerned with protein research. Introduction
to Peptides and Proteins brings together some of the most respected
researchers in protein science to present a remarkably coherent
introduction to modern peptide and protein chemistry. The first
sections of the book delve into - Basic peptide and protein science
from assembly through degradation Traditional and emerging research
methods including those used in bioinformatics and proteomics New
computational approaches and algorithms used to find patterns in
the vast data collected by sequencing projects After providing a
foundation in tools and methods, the authors closely examine six
protein families, including representative classes such as enzymes,
cell-surface receptors, antibodies, fibrous proteins, and bioactive
peptide classes. They concentrate on biochemical mechanisms and
where possible indicate therapeutic or biotechnical possibilities.
Then focusing on clinical aspects, the authors investigate
misfolding as found in prion diseases, miscleavage as found in
Alzheimer's, and mis-sequencing as found with some cancers. Drawing
from some of their own research, the authors summarize recent
achievements and emerging applications. They discuss the use of
proteins and peptides as drugs and the solid-phase synthesis
required for drug production. They also look at the use of peptides
as functional biomolecules and research tools. No longer just th
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