This book constitutes the refereed proceedings of the 15th European Workshop on Computer Performance Engineering, EPEW 2018, held in Paris, France, in October 2018. The 17 papers presented together with the abstracts of two invited talks in this volume were carefully reviewed and selected from 27 submissions. The papers presented at the workshop reflect the diversity of modern performance engineering, with topics ranging from advances in performanceengineering realm, including, dependability and security modeling, performance oriented model verification and testing, hardware and software systems case-studies, applications/extensions of queuing theory and network design