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Rapid, inexpensive, and easy-to-deploy, near-infrared (NIR)
spectroscopy can be used to analyze samples of virtually any
composition, origin, and condition. The Handbook of Near Infrared
Analysis, Fourth Edition, explores the factors necessary to perform
accurate and time- and cost-effective analyses across a growing
spectrum of disciplines. This updated and expanded edition
incorporates the latest advances in instrumentation,
computerization, chemometrics applied to NIR spectroscopy, and
method development in NIR spectroscopy, and underscores current
trends in sample preparation, calibration transfer, process
control, data analysis, instrument performance testing, and
commercial NIR instrumentation. This work offers readers an
unparalleled combination of theoretical foundations, cutting-edge
applications, and practical experience. Additional features include
the following: Explains how to perform accurate as well as time-
and cost-effective analyses. Reviews software-enabled chemometric
methods and other trends in data analysis. Highlights novel
applications in pharmaceuticals, polymers, plastics,
petrochemicals, textiles, foods and beverages, baked products,
agricultural products, biomedicine, nutraceuticals, and counterfeit
detection. Underscores current trends in sample preparation,
calibration transfer, process control, data analysis, and multiple
aspects of commercial NIR instrumentation. Offering the most
complete single-source guide of its kind, the Handbook of Near
Infrared Analysis, Fourth Edition, continues to offer practicing
chemists and spectroscopists an unparalleled combination of
theoretical foundations, cutting-edge applications, and detailed
practical experience provided firsthand by more than 50 experts in
the field.
Since the completion of the first edition of this book, major
developments have occurred in the pharmaceutical industry that have
shaped the field of near-infrared (NIR) spectroscopy. A new
initiative from the U.S. Food and Drug Administration (FDA) to
modernize regulations of pharmaceutical manufacturing and drug
quality has helped position NIR spectroscopy as an effective tool
for pharmaceutical testing. Pharmaceutical and Medical Applications
of Near-Infrared Spectroscopy: Second Edition reflects these
developments and brings readers an up-to-date summary of how this
technique is being applied to pharmaceutical manufacturing. Topics
include: The origins and principles of NIR spectroscopy, including
early instrumentation, spectroscopic theory, and light-particle
interaction The physics of each instrument type, the strengths and
weaknesses of each, and the manufacturers that produce them The
possible advantages of using NIR methods for monitoring or
controlling blending, as well as practical concerns for mixing
processes NIR spectroscopy as applied to traditional granulation,
drug layering, and film coating of beads or granules Pharmaceutical
assays, including qualitative analysis, quantitative analysis,
determination of actives in tablets and capsules, and
considerations for intact dosage form analysis Steps involved in
the validation and acceptance of an NIR spectroscopy method,
including quality assurance, qualification and verification of
instruments, and the International Conference on Harmonization
(ICH) guidelines Medical applications, including those related to
blood glucose measurements, tissue and major organ analysis, fetal
analysis, and cancer research Providing comprehensive coverage of
NIR spectroscopy, from theory, mathematics, application, and
mechanics of NIR analysis, the book supplies ample references to
facilitate further rese
Since the completion of the first edition of this book, major
developments have occurred in the pharmaceutical industry that have
shaped the field of near-infrared (NIR) spectroscopy. A new
initiative from the U.S. Food and Drug Administration (FDA) to
modernize regulations of pharmaceutical manufacturing and drug
quality has helped position NIR spectroscopy as an effective tool
for pharmaceutical testing. Pharmaceutical and Medical Applications
of Near-Infrared Spectroscopy: Second Edition reflects these
developments and brings readers an up-to-date summary of how this
technique is being applied to pharmaceutical manufacturing. Topics
include: The origins and principles of NIR spectroscopy, including
early instrumentation, spectroscopic theory, and light-particle
interaction The physics of each instrument type, the strengths and
weaknesses of each, and the manufacturers that produce them The
possible advantages of using NIR methods for monitoring or
controlling blending, as well as practical concerns for mixing
processes NIR spectroscopy as applied to traditional granulation,
drug layering, and film coating of beads or granules Pharmaceutical
assays, including qualitative analysis, quantitative analysis,
determination of actives in tablets and capsules, and
considerations for intact dosage form analysis Steps involved in
the validation and acceptance of an NIR spectroscopy method,
including quality assurance, qualification and verification of
instruments, and the International Conference on Harmonization
(ICH) guidelines Medical applications, including those related to
blood glucose measurements, tissue and major organ analysis, fetal
analysis, and cancer research Providing comprehensive coverage of
NIR spectroscopy, from theory, mathematics, application, and
mechanics of NIR analysis, the book supplies ample references to
facilitate further rese
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