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Ion channels play a vital role in basic physiological functions
such as generation of electrical activity in nerves and muscle,
control of cardiac excitability, intracellular signaling, hormone
secretion, cell proliferation and many other biological processes.
Because of their prevalence and the critical role they play in
virtually all tissue types and organs, ion channels are also
involved in a number of pathophysiological conditions. The aim of
this volume is to review recent advances in the field of ion
channel related diseases. Following an overview chapter summarizing
the current state of ion channel screening technologies, five
topics covering areas such as cancer, cardiac arrhythmias, cystic
fibrosis, and pain have been selected, and the current state of
knowledge is presented by leading experts in their field. Each
chapter is structured to cover the biological rationale for the
target, the current status in the development of agents to treat
the disease, and future prospects and challenges facing each
therapeutic area. The reader will receive a critical overview
covering the progress made in the rapidly developing and complex
field of ion channels and diseases.
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