The 22nd Conference on Autonomous Mobile Systems (AMS 2012) provides a platform for idea exchange, scientific discussion and cooperation for scientists from universities as well as industry. Autonomous mobile systems as well as their practical approach are in the center of interest. The presented selection of articles focuses on approaches from the fields of perception and sensors, mapping and localization, control, navigation, micro- and nano robotics, machine learning, autonomous cars, humanoid robots, system architectures and the application in autonomous mobile systems.