The book discusses novel visualization techniques driven by the needs in medicine and life sciences as well as new application areas and challenges for visualization within these fields. It presents ideas and concepts for visual analysis of data from scientific studies of living organs or to the delivery of healthcare. Target scientific domains include the entire field of biology at all scales - from genes and proteins to organs and populations - as well as interdisciplinary research based on technological advances such as bioinformatics, biomedicine, biochemistry, or biophysics. Moreover, they comprise the field of medicine and the application of science and technology to healthcare problems. This book does not only present basic research pushing the state of the art in the field of visualization, but it also documents the impact in the fields of medicine and life sciences.

Visualization technology is becoming increasingly important for medical and biomedical data processing and analysis. The interaction between visualization and medicine is one of the fastest expanding fields, both scientifically and commercially. This book discusses some of the latest visualization techniques and systems for effective analysis of such diverse, large, complex, and multi-source data.

Geometric Modeling and Scientific Visualization are both established disciplines, each with their own series of workshops, conferences and journals. But clearly both disciplines overlap; this observation led to the idea of composing a book on Geometric Modeling for Scientific Visualization.

This book emerged from a DoE/NSF-sponsored workshop, held in Tahoe City, California, October 2000. About fifty invited participants presented state-of-the-art research on topics such as: - terrain modeling- multiresolution subdivision- wavelet-based scientific data compression- topology-based visualization- data structures, data organization and indexing schemes for scientific data visualization.All invited papers were carefully refereed, resulting in this collection. The book will be of great interest to researchers, graduate students and professionals dealing with scientific visualization and its applications.

For some time, medicine has been an important driver for the development of data processing and visualization techniques. Improved technology offers the capacity to generate larger and more complex data sets related to imaging and simulation. This, in turn, creates the need for more effective visualization tools for medical practitioners to interpret and utilize data in meaningful ways.

The first edition of Visualization in Medicine and Life Sciences (VMLS) emerged from a workshop convened to explore the significant data visualization challenges created by emerging technologies in the life sciences. The workshop and the book addressed questions of whether medical data visualization approaches can be devised or improved to meet these challenges, with the promise of ultimately being adopted by medical experts.

Visualization in Medicine and Life Sciences II follows the second international VMLS workshop, held in Bremerhaven, Germany, in July 2009. Internationally renowned experts from the visualization and driving application areas came together for this second workshop.

The book presents peer-reviewed research and survey papers which document and discuss the progress made, explore new approaches to data visualization, and assess new challenges and research directions.

The assembled papers span the frontiers of VMLS, examining these topics:

* Feature Extraction

* Classification

* Volumes and Shapes

* Tensor Visualization

* Visualizing Genes, Proteins, and Molecules"

The goal of visualization is the accurate, interactive, and intuitive presentation of data. Complex numerical simulations, high-resolution imaging devices and incre- ingly common environment-embedded sensors are the primary generators of m- sive data sets. Being able to derive scienti?c insight from data increasingly depends on having mathematical and perceptual models to provide the necessary foundation for effective data analysis and comprehension. The peer-reviewed state-of-the-art research papers included in this book focus on continuous data models, such as is common in medical imaging or computational modeling. From the viewpoint of a visualization scientist, we typically collaborate with an application scientist or engineer who needs to visually explore or study an object which is given by a set of sample points, which originally may or may not have been connected by a mesh. At some point, one generally employs low-order piecewise polynomial approximationsof an object, using one or several dependent functions. In order to have an understanding of a higher-dimensional geometrical "object" or function, ef?cient algorithms supporting real-time analysis and manipulation (- tation, zooming) are needed. Often, the data represents 3D or even time-varying 3D phenomena (such as medical data), and the access to different layers (slices) and structures (the underlying topology) comprising such data is needed.

The nature of the physical Universe has been increasingly better understood in recent years, and cosmological concepts have undergone a rapid evolution (see, e.g., [11], [2],or [5]). Although there are alternate theories, it is generally believed that the large-scale relationships and homogeneities that we see can only be explainedby having the universe expand suddenlyin a very early "in?ationary" period. Subsequent evolution of the Universe is described by the Hubble expansion, the observation that the galaxies are ?ying away from each other. We can attribute di?erent rates of this expansion to domination of di?erent cosmological processes, beginning with radiation, evolving to matter domination, and, relatively recently, to vacuum domination (the Cosmological Constant term)[4]. We assume throughout that we will be relying as much as possible on observational data, with simulations used only for limited purposes, e.g., the appearance of the Milky Wayfrom nearbyintergalactic viewpoints. The visualization of large-scale astronomical data sets using?xed, non-interactive animations has a long history. Several books and ?lms exist, ranging from "Cosmic View: The Universe in Forty Jumps" [3] by Kees Boeke to "Powers of 10" [6,13] by Charles and Ray Eames, and the recent Imax ?lm "Cosmic Voyage" [15]. We have added our own contribution [9], "Cosmic Clock," which is an animation based entirely on the concepts and implementation described in this paper.

The goal of visualization is the accurate, interactive, and intuitive presentation of data. Complex numerical simulations, high-resolution imaging devices and incre- ingly common environment-embedded sensors are the primary generators of m- sive data sets. Being able to derive scienti?c insight from data increasingly depends on having mathematical and perceptual models to provide the necessary foundation for effective data analysis and comprehension. The peer-reviewed state-of-the-art research papers included in this book focus on continuous data models, such as is common in medical imaging or computational modeling. From the viewpoint of a visualization scientist, we typically collaborate with an application scientist or engineer who needs to visually explore or study an object which is given by a set of sample points, which originally may or may not have been connected by a mesh. At some point, one generally employs low-order piecewise polynomial approximationsof an object, using one or several dependent functions. In order to have an understanding of a higher-dimensional geometrical "object" or function, ef?cient algorithms supporting real-time analysis and manipulation (- tation, zooming) are needed. Often, the data represents 3D or even time-varying 3D phenomena (such as medical data), and the access to different layers (slices) and structures (the underlying topology) comprising such data is needed.

The book discusses novel visualization techniques driven by the needs in medicine and life sciences as well as new application areas and challenges for visualization within these fields. It presents ideas and concepts for visual analysis of data from scientific studies of living organs or to the delivery of healthcare. Target scientific domains include the entire field of biology at all scales - from genes and proteins to organs and populations - as well as interdisciplinary research based on technological advances such as bioinformatics, biomedicine, biochemistry, or biophysics. Moreover, they comprise the field of medicine and the application of science and technology to healthcare problems. This book does not only present basic research pushing the state of the art in the field of visualization, but it also documents the impact in the fields of medicine and life sciences.

For some time, medicine has been an important driver for the development of data processing and visualization techniques. Improved technology offers the capacity to generate larger and more complex data sets related to imaging and simulation. This, in turn, creates the need for more effective visualization tools for medical practitioners to interpret and utilize data in meaningful ways. The first edition of Visualization in Medicine and Life Sciences (VMLS) emerged from a workshop convened to explore the significant data visualization challenges created by emerging technologies in the life sciences. The workshop and the book addressed questions of whether medical data visualization approaches can be devised or improved to meet these challenges, with the promise of ultimately being adopted by medical experts. Visualization in Medicine and Life Sciences II follows the second international VMLS workshop, held in Bremerhaven, Germany, in July 2009. Internationally renowned experts from the visualization and driving application areas came together for this second workshop. The book presents peer-reviewed research and survey papers which document and discuss the progress made, explore new approaches to data visualization, and assess new challenges and research directions.