In the rapidly developing area of neuroimmunology, primary at- tention has been given thus far to the bidirectional exchange of information between the immune system and the neuroendocrine system. Several recent texts on this subject are based alm ost exclu- sively on experimental and clinical data obtained in mammalian species. One of the interesting insights gained from these studies is that the chemical messenger substances used in this exchange by either system are the same, or at least closely related to each other. Cytokines, primarily thought of as being dispatched by cells of the immune system, have recently been identified to be products of neural, in particular, glial elements. Conversely, neuropeptides for- merly considered to be characteristic of the neuroendocrine apparatus are now known to be manufactured and dispatched by immuno- regulatory cells as weIl. The present text is the first to provide an overview of the rich body of information obtained in aseries of broadly based comparative studies. This work in representatives of higher invertebrates has opened new vistas, in particular, regarding the immunomodulatory role played by opioid and other neuropeptides as signal molecules in the ceIl-mediated internal regulation of the immune system.

An international symposium titled "Functional Morphology of Neuroendocrine Systems: Evolutionary and Environmental Aspects" was held on the occasion of the 60th birthday of Professor Andreas Oksche, head of the Department of Anatomy and Cytobiology, Justus Liebig University, Giessen, FRG. This volume containing the texts of the plenary lectures and the abstracts of poster contributions presented at the symposium on July 30-August 1, 1986 in Giessen, reflects the rapid expansion of the field of neuroendocrinology. New insights into the interactions between neurons acting as endocrine cells and conventional neurons have been gained by the use of newly developed neurobiological techniques (e. g. , immuno- cytochemistry, tracing of neuronal connections by means of anterograde and retrograde axonal transport of identified molec- ules, electrophysiological recordings in vivo and in vitro). The findings of the past few years have extended the fundamental concept of neurosecretion introduced by Ernst and Berta Scharrer in close cooperation with Wolfgang Bargmann. An important landmark was the discovery that neurons containing classical neurosecretory products not only project to neurohemal release organs but also establish hypothalamic and extrahypothalamic neuro-neuronal contacts. In some of these neurons monoamine transmitters are known to co-exist with opioid and other neuro- peptides. Different types of transmitters may even be co-localized in the same dense core vesicles. The use of extremely sensitive techniques which allow the detection of minute quantities of messenger substances has provided evidence that several of these substances have been well preserved in the course of evolution.