This book constitutes the refereed proceedings of the 14th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2021, held virtually due to the COVID-19 crisis, in February 2021. The conference was held virtually due to the COVID-19 crisis. The 13 full papers included in this book were carefully reviewed and selected from 265 submissions. The papers selected to be included in this book contribute to the understanding of relevant trends of current research on Biomedical Engineering Systems and Technologies, including: Pattern Recognition and Machine Learning, Application of Health Informatics in Clinical Cases, Evaluation and Use of Healthcare IT, Medical Signal Acquisition, Analysis and Processing, Data Mining and Data Analysis, Decision Support Systems, e-Health, e-Health Applications, Mobile Technologies for Healthcare Applications and Medical Devices design.