A small cadre of scientists- collabourators and competitors- are determined to develop a vaccine for malaria, a feat most tropical disease experts have long considered impossible. Skepticism, doubt, and a host of logistical and financial obstacles dog their quest. Success may ultimately elude them. Why, and how, do they persist?The kind of person who decides to combat malaria must have a very rare combination of attributes: dogged enough to keep going when results are slow independent enough to continue, often alone, when other, more popular, causes distract attention from their work self-confident enough in the importance of the work to persist when the beneficiaries may reside thousands of miles distant. Above all, taking on a challenge of this scale requires a fearlessly bold moral imagination that defies reason. Bill Shore tells the story of man's attempt to combat malaria through the drama of the handful of scientists and organizations currently seeking to curb, and in one case, at least, cure, the world of this most ancient and persistent scourge. It is a drama to the death.The story of these uncompromising scientists serves as a springboard for Shore's passionate inquiry into the character and moral fabric of those who devote their lives to solving the world's most pressing and perplexing problems. During his career as a social entrepreneur Shore has persistently wrestled with this fundamental question: What does it take to make a truly transformational difference? To achieve not just incremental progress but a game changer or, in the case of malaria, a life saver? In this moving and inspiring book, he offers compelling answers.

In this wise and inspiring book, social entrepreneur Bill Shore shows us how to make the most of life and do something that counts. Like the cathedral builders of an earlier time, the visionaries described in this memoir share a single desire: to create something that endures. The extraordinary people Shore has met on his travels represent a new movement of citizens who are tapping into the vast resources of the private sector to improve public life. Among them are:

-- Gary Mulhair, who has created unprecedented jobs and wealth at the largest self-supporting human-service organization of its kind, Pioneer Human Services of Seattle.

-- Nancy Carstedt of the Chicago Childrenís Choir, which provides thousands of children their first introduction to music.

-- Geoffrey Canada, who has made a safe haven for more than four thousand inner-city children in New York City, from Hell's Kitchen to Harlem.

These leaders, and many others described in these pages, have built important new cathedrals within their communities, and by doing so they have transformed lives, including their own.