Organocatalysis are an important tool for greener catalytic processes due to the lack of precious metals used. This book explores different organocatalysts and their use in synthesis. Topics covered include zwitterionic imidazolium salt catalysts, asymmetric catalysts in aqueous media, beaker yeast catalysis, organocatalysts for Aldol and Michael reactions, amino acid-based organocatalysts, and Broensted acidic surfactant organocatalysts.

Cancer is an incredibly diverse and difficult disease to treat, and even after decades of research there is no definitive cure. Therefore, it is highly crucial to search for novel and new organic molecules with high potency, low toxicity, and low mutagenicity with selective anticancer properties that are able to overcome frequently developed resistance to available drugs. Heterocyclic anticancer agents are an important class of drugs for cancer therapies. This book explores different heterocycles and their use as anticancer therapies. Topics covered include different heterocyclic derivatives, the impact of heterocycles on anticancer agent development, and naturally occurring heterocycles.

Activities and biological relationships of terpenes. An accurate assessment of where and what terpenes can lead to. Discusses how microbes, in particular the actinomycetales, have well over 400 different gene clusters that produce terpenes. Arranged by biological activities and usage. Provides information on eukaryotic enzymes that have been shown to be a source of "ethnobotanical" terpenes

Tellurium, a well-known chalcogen, finds potential applications in various fields from chemistry to other branches of science such as nanotechnology and macromolecular science. However, its safety must also be taken into consideration when exploring its industrial applications. This book explores the breadth of tellurium's applications, outlines strategies for industrial use, and describes the safety concerns of this element.

Extensive experimentation and high failure rates are a well-recognised downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry, Second Edition reveals how medicinal chemistry can play a direct role in addressing this issue. After providing essential context to the growth of green chemistry in relation to drug discovery, the book goes on to identify a broad range of practical techniques and useful insights, revealing how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discovery process. Drawing on the knowledge of a global team of experts, Sustainable and Green Approaches in Medicinal Chemistry 2e encourages the growth of green medicinal chemistry, and supports medicinal chemists, drug discovery researchers, pharmacologists and all those in related fields across both academia and industry in integrating these approaches into their own work. This first volume of the second edition covers synthesis methods following green chemistry principles, contributing to sustainability by saving energy, using lesser toxic reagents/solvents/catalysts and environmentally benign sources including plants and agricultural materials.

Extensive experimentation and high failure rates are a well-recognized downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry 2e reveals how medicinal chemistry can play a direct role in addressing this issue. After providing essential context to the growth of green chemistry in relation to drug discovery, the book goes on to identify a broad range of practical techniques and useful insights, revealing how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discovery process. Drawing on the knowledge of a global team of experts, Sustainable and Green Approaches in Medicinal Chemistry, Second Edition encourages the growth of green medicinal chemistry, and supports medicinal chemists, drug discovery researchers, pharmacologists and all those in related fields across both academia and industry in integrating these approaches into their own work. This second volume of the second edition includes the development of nanoparticles and nanocomposites, as well as the application of ultrasound and microwave-induced methods; studies solventless synthesis; defines the role of steroids; studies reactions in aqueous solution; identifies enzyme-mediated reactions; investigates ionic liquids and deep eutectic solvents; explores natural products; investigates solid supports; realizes the effects of salts; focuses on combinatorial chemistry; develops one-pot methods; analyzes multi-component reactions; investigates dipole moment values; and examines computer-assisted methods.

Natural Products as Anticancer Agents introduces the different types of natural products that have been used for cancer treatment. Divided into four parts, covering anticancer agents derived from terrestrial plants, anticancer agents derived from the marine environment, and anticancer agents derived from microorganisms, as well as evaluation of new anticancer agents, each part includes discussion of the properties, synthesis/extraction, storage, mechanism of action, and usage of the molecules. Discussion of the future prospects in anticancer natural products—including several new trends and an indication of where research in this area is likely to go in the future—is also included.

Organic and medicinal chemistry are definitely the principal branches of chemistry as they are more widely studied than any other subjects in chemistry. Very often, organic and medicinal chemistry have been defined as a hybrid discipline of many other subjects that include biology, chemistry, medicine and pharmacy. The synthesis of molecules, mechanism of a process, studies of new reagents, natural products, biological and pharmacological evaluation of molecules against different components of cells are the key subjects in these two areas. On the basis of unlimited possibilities, one can imagine several scopes exist for students, researchers and industrialists to study and explore organic and medicinal chemistry. In this book, an attempt has been made to include diverse research topics to benefit the readers from different standpoints. This book has nine chapters (Volume 2) from active authors. Bhalla and his group have written two chapters in this volume. In the first chapter, Berry and Bhalla have demonstrated recent progress on the pharmacological profile of pyrazole and imidazole conjugates. In the second chapter, Kumari and Bhalla have explored the synthesis of optically active beta lactams. Sahoo and Banik have explored new quinazolines synthesis and their medicinal and pharmacological properties in Chapter Three. Perchyonok has described natural biomaterials for veterinary therapy through an in vitro approach in the fourth chapter. In the fifth chapter, Perchyonok et al. have also reported studies on cytotoxicity biomaterials containing chitosan hydrogels. Philips has demonstrated the synthesis and applications of pharmacologically relevant phosphonates and phosphinites in Chapter Six. Basu and Banik have explored apoptosis in the inhibition of cancer in Chapter Seven. Maji and Ganguly have demonstrated the use of mushrooms as a food in Chapter Eight. Bandyopadhyay et al. have studied key enzymes that are responsible in cancer and their mechanism of action in the ninth chapter. Scientists are convinced that organic and medicinal chemistry have no boundaries in science. The application of these chemical and medicinal sciences is huge and they are related to many significant discoveries. On this basis, the book will be useful for chemists, biologists, clinicians, pharmacists, biotechnologists, industrialists and engineers who are working in the field of interdisciplinary science as well as specific chemical and medicinal science.