Dit is aand in Wemelstad. Mense en diere slaap rustig – oftewel, sommige. Ander is in die laat ure eers oppad erens heen en hulle beleef opwindende dinge soos ’n Boekwurmaand in die biblioteek, ’n partytjie in die park of aanskou selfs hoe die polisie ’n dief vastrek.

Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

Unlike some other reproductions of classic texts (1) We have not used OCR(Optical Character Recognition), as this leads to bad quality books with introduced typos. (2) In books where there are images such as portraits, maps, sketches etc We have endeavoured to keep the quality of these images, so they represent accurately the original artefact. Although occasionally there may be certain imperfections with these old texts, we feel they deserve to be made available for future generations to enjoy.

Feeding the world, climate change, biodiversity, antibiotics, plastics, pandemics - the list of concerns seems endless. But what is most pressing, and what should we do first? Do we all need to become vegetarian? How can we fly in a low-carbon world? How can we take control of technology? And, given the global nature of the challenges we now face, what on Earth can any of us do, as individuals? Mike Berners-Lee has crunched the numbers and plotted a course of action that is full of hope, practical, and enjoyable. This is the big-picture perspective on the environmental and economic challenges of our day, laid out in one place, and traced through to the underlying roots - questions of how we live and think. This updated edition has new material on protests, pandemics, wildfires, investments, carbon targets and of course, on the key question: given all this, what can I do?

In twelve dreams, Robert, a boy who hates math, meets a Number Devil, who leads him to discover the amazing world of numbers: infinite numbers, prime numbers, Fibonacci numbers, numbers that magically appear in triangles, and numbers that expand without end. As we dream with him, we are taken further and further into mathematical theory, where ideas eventually take flight, until everyone -- from those who fumble over fractions to those who solve complex equations in their heads -- winds up marveling at what numbers can do.

In diesem Werk werden Moeglichkeiten der Wirkstoffverabreichung dargestellt, wobei physikalische und pharmakokinetische Modelle zur Erzielung der gewunschten Profile und Ansatze herangezogen werden. Nach einem UEberblick uber die Wirkstoffaufnahme und die physiologischen Modelle werden in den Kapiteln uber die oralen Verabreichungswege (die haufigste Form der Verabreichung) die PBPK und verschiedene moegliche Darreichungsformen beschrieben. Bei der systemischen transdermalen Verabreichung ist es notwendig, die Pharmakokinetik der Formulierung und des Wirkstoffs zu verstehen, um die Formulierung von der ersten Konzeption uber die gesamte Entwicklung darauf auszurichten. In weiteren Kapiteln werden die biologischen und praktischen Ansatze bei der pulmonalen und mukosalen Verabreichung besprochen. Fur den Fall der Notfallversorgung betrachten die Autoren die Beziehung zwischen parenteralen Infusionsprofilen und PK/PD. In den letzten Kapiteln werden aktuelle Trends dargestellt, darunter virtuelle Experimente zur Verdeutlichung von Mechanismen sowie moderne Ansatze in der Wirkstoffverabreichung und personalisierten Medizin. Das Werk Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics eignet sich nicht nur perfekt fur Wissenschaftler, Forscher in der Industrie, Doktoranden und Postdoktoranden in den Bereichen der Pharmawissenschaft und Pharmatechnik, sondern verdient auch einen Platz in den Bucherregalen von Experten, die sich mit Formulierungen, Pharmakokinetik und klinischer Pharmakologie beschaftigen.

Named one of the greatest minds of the 20th century by Time, Tim Berners-Lee is responsible for one of that century's most important advancements: the world wide web.  Now, this low-profile genius-who never personally profitted from his invention -offers a compelling protrait of his invention.  He reveals the Web's origins and the creation of the now ubiquitous http and www acronyms and shares his views on such critical issues as censorship, privacy, the increasing power of softeware companies , and the need to find the ideal balance between commercial and social forces.  He offers insights into the true nature of the Web, showing readers how to use it to its fullest advantage.  And he presents his own plan for the Web's future, calling for the active support and participation of programmers, computer manufacturers, and social organizations to manage and maintain this valuable resource so that it can remain a powerful force for social change and an outlet for individual creativity.

This book provides a comprehensive overview of our current understanding of binge eating, which is characterized by the uncontrollable consumption of large amounts of food in a discrete time period. Written by experts on eating disorders, it first introduces the phenotype of binge eating, including its epidemiology and assessment. It then describes the underlying neurobiological alterations, drawing on cutting-edge animal models and human studies to do so. In addition, it extensively discusses current treatment models, including medication, psychotherapy, self-interventions and disease prevention. Lastly, an outlook on the future research agenda rounds out the coverage. Given binge eating's current status as an under-researched symptom, but one shared across many eating disorders, this book provides an up-to-date, integrative and comprehensive synthesis of recent research and offers a valuable reference for scientists and clinicians alike.

The focus of this thesis is the interplay of synchrony and adaptivity in complex networks. Synchronization is a ubiquitous phenomenon observed in different contexts in physics, chemistry, biology, neuroscience, medicine, socioeconomic systems, and engineering. Most prominently, synchronization takes place in the brain, where it is associated with cognitive capacities like learning and memory, but is also a characteristic of neurological diseases like Parkinson and epilepsy. Adaptivity is common in many networks in nature and technology, where the connectivity changes in time, i.e., the strength of the coupling is continuously adjusted depending upon the dynamic state of the system, for instance synaptic neuronal plasticity in the brain. This research contributes to a fundamental understanding of various synchronization patterns, including hierarchical multifrequency clusters, chimeras and other partial synchronization states. After a concise survey of the fundamentals of adaptive and complex dynamical networks and synaptic plasticity, in the first part of the thesis the existence and stability of cluster synchronization in globally coupled adaptive networks is discussed for simple paradigmatic phase oscillators as well as for a more realistic neuronal oscillator model with spike-timing dependent plasticity. In the second part of the thesis the interplay of adaptivity and connectivity is investigated for more complex network structures like nonlocally coupled rings, random networks, and multilayer systems. Besides presenting a plethora of novel, sometimes intriguing patterns of synchrony, the thesis makes a number of pioneering methodological advances, where rigorous mathematical proofs are given in the Appendices. These results are of interest not only from a fundamental point of view, but also with respect to challenging applications in neuroscience and technological systems.