This book constitutes the refereed post-conference proceedings of the 6th EAI International Conference Computer on Science and Engineering in Health Services (COMPSE 2022), which took place in Mexico City and online, June 28th, 2022. The papers are grouped on thematic topics: application of tools delivered by the COVID-19 pandemic; health services; computer and data science; and industry 4.0 in logistics and supply chain. The content is relevant to researchers, academics, students and professionals.