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This book is about melanoma-its biology, immunology, and pathology,
as well as the initial use of powerful genomic tools to study its
fundamental mole- lar and genetic characteristics. The study of
cancer will be profoundly impacted by the Human Genome Project. I
would like to discuss some of these changes. The first draft of the
human genome sequence was announced in June 2000, and we have just
scratched the surface of the changes it will engender in medicine.
A relevant question is what are the long-term effects of the Human
Genome Project for medicine? I would argue that there are three,
and each of these three point toward the view that systems biology
will dominate biology and medicine of the 21st century. First, the
Human Genome Project introduced a new type of s- ence-discovery
science. Discovery science takes a biological system (e. g. , the
genome) and defines all of its elements (e. g. , the sequences of
the 24 human ch- mosomes). Thus, it creates a rich infrastructure
from which the classical hypo- esis-driven science can be done more
effectively. The effective integration of discovery- and
hypothesis-driven science is a key for systems approaches to bi-
ogy and medicine. Second, the Human Genome Project has provided a
"periodic table of life.
This book is about melanoma-its biology, immunology, and pathology,
as well as the initial use of powerful genomic tools to study its
fundamental mole- lar and genetic characteristics. The study of
cancer will be profoundly impacted by the Human Genome Project. I
would like to discuss some of these changes. The first draft of the
human genome sequence was announced in June 2000, and we have just
scratched the surface of the changes it will engender in medicine.
A relevant question is what are the long-term effects of the Human
Genome Project for medicine? I would argue that there are three,
and each of these three point toward the view that systems biology
will dominate biology and medicine of the 21st century. First, the
Human Genome Project introduced a new type of s- ence-discovery
science. Discovery science takes a biological system (e. g. , the
genome) and defines all of its elements (e. g. , the sequences of
the 24 human ch- mosomes). Thus, it creates a rich infrastructure
from which the classical hypo- esis-driven science can be done more
effectively. The effective integration of discovery- and
hypothesis-driven science is a key for systems approaches to bi-
ogy and medicine. Second, the Human Genome Project has provided a
"periodic table of life.
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