By day it's cats and dogs, by night it's mice and rats, and if the birds don't get you then the insects will. But hey, that's life at the bottom of the food chain. One normal summer day, every mammal, reptile and avian on the entire planet unite with a single goal: the extermination of mankind. Three days later the insects join in, and it doesn't stop. It never stops. Ten years later, scattered pockets of humanity fight to keep flesh and sanity intact as they strive to unravel the mystery of what made the animals change, and more importantly, how to change them back.

The animals are getting smarter. The ants have learned how to take out entire settlements in a single night. As Mother Nature closes in on humanity's remnants, a vital piece of technology is stolen from Compton Pit. Five people set off in pursuit, desperate to recover the item before knowledge of its existence draws every gun from miles around. Their journey will take them through teeth-infested territory long abandoned by the likes of man, all the way to a legendary city built on the remains of America's last aircraft carrier. The floating utopia is anything but. Corruption rules its darkest corners, and there are things in the ocean far worse than anything that walks on land.