The world as we know it is about to end, and the Runaways are the only hope to prevent it

Y: The Last Man is the gripping saga of Yorick Brown, an unemployed and unmotivated slacker who discovers that he is the only male left in the world after a plague of unknown origin instantly kills every mammal with a Y chromosome. Accompanied by his mischievous monkey and the mysterious Agent 355, York embarks on a transcontinental journey to find his girlfriend and discover why he is the last man on Earth. In this third volume, Yorick's unbalanced sister Hero tracks him to San Francisco, only to find him seemingly succumbing to the male-killing plague after losing his still-unused engagement ring to agents of the Setauket Ring. Plus, Yorick, Agent 355, and Dr. Mann ship out across the Pacific to Japan in pursuit of Yorick's stolen monkey Ampersand, whose innards may hold the key to mankind's future. This volume collects Y: The Last Man #24-36.