This volume presents recent data on the latest achievements in new and emerging technologies for biomarkers and for innovations in their assessment. The chapters cover topics such as activation of microglia and macrophages in neurodegenerative diseases; oxidative stress and cellular dysfunction in neurodegenerative diseases; TSPO PET imaging as a biomarker of neuroinflammation in neurodegenerative disorders; and imaging biomarkers in Huntington's disease and amyotrophic lateral sclerosis. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and comprehensive, Neurodegenerative Diseases Biomarkers: Towards Translating Research to Clinical Practice is a valuable resource for both experimental and clinical experts in the field of neurodegenerative diseases who are looking to expand their knowledge of novel biomarkers in different types of neurodegenerative diseases.

This volume presents recent data on the latest achievements in new and emerging technologies for biomarkers and for innovations in their assessment. The chapters cover topics such as activation of microglia and macrophages in neurodegenerative diseases; oxidative stress and cellular dysfunction in neurodegenerative diseases; TSPO PET imaging as a biomarker of neuroinflammation in neurodegenerative disorders; and imaging biomarkers in Huntington's disease and amyotrophic lateral sclerosis. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and comprehensive, Neurodegenerative Diseases Biomarkers: Towards Translating Research to Clinical Practice is a valuable resource for both experimental and clinical experts in the field of neurodegenerative diseases who are looking to expand their knowledge of novel biomarkers in different types of neurodegenerative diseases.

From pathology to treatment, MicroRNAs in Diseases and Disorders highlights the role of microRNAs (miRNAs) in the development and progression of a variety of diseases, including cancer, neurological disease, endocrine disease and autoimmune disease, and underscores the utilization of miRNA targets in the treatment of these conditions. Providing a comprehensive account, this book also includes the identification of miRNAs as diagnostic and prognostic biomarkers for disease, as well as evaluates translational value from clinical trials using synthesized and functionalized miRNA mimics and inhibitors. With a global contribution list and chapters from leading experts across the field, MicroRNAs in Diseases and Disorders is an invaluable reference to miRNA researchers and health professionals in a variety of disease areas in government, academia and industry. The book will also appeal to pharmaceutical and medicinal chemists with an interest in miRNA targeting therapeutics, as well as to advanced students in chemical biology and drug discovery.

Fifth-century Greek tragedy contains some of the most fascinating and important stage-ghosts in Western literature, whether the talkative Persian king Darius, who is evoked from the Underworld in Aeschylus’ Persians, or the murdered Trojan prince Polydorus, who seeks burial for his exposed corpse in Euripides’ Hecuba. These manifest figures can tell us a vast amount about the abilities of the tragic dead, particularly in relation to the nature, extent and limitations of their interaction with the living through, for example, ghost-raising ceremonies and dreams. Beyond these manifest dead, tragedy presents a wealth of invisible dead whose anger and desire for revenge bubble up from the Underworld, and whose honour and dishonour occupy the minds and influence the actions of the living. Combining both these manifest and invisible dead, this book examines harmful interaction between the living and the dead, i.e. how the living can harm the dead, and how the dead can harm the living. This includes discussions on the extent to which the dead are aware of and can react to honourable or dishonourable treatment by the living, the social stratification of the Underworld, the consequences of corpse exposure and mutilation for both the living and the dead, and how the dead can use and collaborate with avenging agents, such as the gods, the living and the Erinyes.

Written with passion for anyone interested in seeing an end to the illegal trade in elephant ivory and rhino horn, this book shows how, by working together, people all over the world who care about these animals are gradually bringing about change for the better. It takes an overview of how the current situation came to pass by exploring poaching and its devastating consequences and the pivotal role of organized crime. The discussion of how matters are starting to improve covers the investigation and monitoring of ivory markets, sustainable uses and the key role of local communities.Enforcement of the law is vital in this story. Enter the enforcers, the technology they use to defeat the poachers and the evidence they require to prosecute offenders. Cases, some deeply shocking, are included, as well as a number of fascinating case studies, while the exploits of organized crime gangs make lively, as well as disturbing reading. Throughout the message is clear. We can and must save these animals from extinction.

A rise in the number of young and old patients suffering from a stroke or traumatic brain injury has led to the need for better drug development and treatment, as well as diagnosis and prevention of ischemic stroke and traumatic brain injury. This book provides a comprehensive overview of scientific advancements in these areas. Chapters provide the latest knowledge in neuroscience, biotechnology, and personalized medicine applicable to acute brain injuries. Development of neuroprotective drugs is treated in detail. Chemical biomarkers for detection, imaging and preventative strategies are covered to provide medicinal chemists with a broad view of translational aspects of the field. This book will be useful to postgraduate students and researchers in medicinal chemistry and pharmacology as well as specialists in the acute brain injury field.