This issue of Surgical Pathology Clinics, Guest Edited by Dr. Brooke Howitt, will focus on practical issues and updates around Gynecologic Pathology. This issue is one of four selected each year by the series Consulting Editor, Jason L. Hornick. Topics include, but are not limited to, Non-HPV associated squamous neoplasia of the vulva and vagina; HPV-associated squamous neoplasia of the lower female genital tract; Cervical glandular neoplasia: classification and staging; Preinvasive lesions of the endometrium; Endometrial carcinoma: Grossing, frozen section evaluation, staging, and senitnel lymph node evaluation; High grade endometrial carcinomas: Classification with molecular insights; Uterine mesenchymal tumors: Classification, staging, and updates in molecular testing; Smooth muscle neoplasia of the female genital tract; Germ cell tumors of the female genital tract; Fallopian tube neoplasia and mimics; Low grade serous neoplasia of the female genital tract; Ovarian high grade serous carcinoma: Staging, assessing site of origin and the post-neoadjuvant chemotherapy setting; Ovarian mucinous tumors; Endometrioid and clear cell tumors of the ovary; and Ovarian sex cord stromal tumors.