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This book provides a comprehensive overview of the cascade of
events activated in the body following the implant of biomaterials
and devices. It is one of the first books to shed light on the role
of the host immune response on therapeutic efficacy, and reviews
the state-of-the-art for both basic science and medical
applications. The text examines advantages and disadvantages of the
use of synthetic versus natural biomaterials. Particular emphasis
is placed on the role of biomimicry in the development of smart
strategies able to modulate infiltrating immune cells, thus
reducing side effects (such as acute and chronic inflammation,
fibrosis and/or implant rejection) and improving the therapeutic
outcome (healing, tissue restoration). Current cutting-edge
approaches in tissue engineering, regenerative medicine, and
nanomedicine offer the latest insights into the role
immunomodulation in improving tolerance during tissue transplant in
the treatment of orthopaedic, pancreatic, and hepatic diseases.
"Immune Response to Implanted Materials and Devices" is intended
for an audience of graduate students and professional researchers
in both academia and industry interested in the development of
smart strategies, which are able to exploit the self-healing
properties of the body and achieve functional tissue restoration.
This book provides a comprehensive overview of the cascade of
events activated in the body following the implant of biomaterials
and devices. It is one of the first books to shed light on the role
of the host immune response on therapeutic efficacy, and reviews
the state-of-the-art for both basic science and medical
applications. The text examines advantages and disadvantages of the
use of synthetic versus natural biomaterials. Particular emphasis
is placed on the role of biomimicry in the development of smart
strategies able to modulate infiltrating immune cells, thus
reducing side effects (such as acute and chronic inflammation,
fibrosis and/or implant rejection) and improving the therapeutic
outcome (healing, tissue restoration). Current cutting-edge
approaches in tissue engineering, regenerative medicine, and
nanomedicine offer the latest insights into the role
immunomodulation in improving tolerance during tissue transplant in
the treatment of orthopaedic, pancreatic, and hepatic diseases.
"Immune Response to Implanted Materials and Devices" is intended
for an audience of graduate students and professional researchers
in both academia and industry interested in the development of
smart strategies, which are able to exploit the self-healing
properties of the body and achieve functional tissue restoration.
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