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Gliomas encompass a wide variety of particularly devastating
tumors, for which efficient therapies are not available. Their
etiology remains mostly undetermined: so far, only exposure to high
dose therapeutic radiation has been firmly established as a risk
factor, but other plausible causes include genetic syndromes,
familial aggregation, and genetic polymorphisms. The clinical
performance status and patient age at diagnosis are definite
features associated with outcome, but recent evidences suggest that
tumor's molecular traits are also major determinants of prognosis.
This book aims to review and discuss how molecular determinants may
affect glioma risk and patient outcome, with a very special
emphasis in glioblastoma multiforme, the most common and malignant
glioma subtype. To do so, Part I presents a general introduction
that summarizes the classification, epidemiology, and treatment of
gliomas, while devoting particular attention to potential
etiological factors and molecular alterations of these tumors. Part
II presents original research studies emphasizing the relevance of
particular biomarkers of glioma, particularly at the levels of
glioma risk and patient prognosis.
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