This volume constitutes the refereed proceedings of the 29th European Conference on Systems, Software and Services Process Improvement, EuroSPI 2022, held in Salzburg, Austria, in August-September 2022.The 49 full papers and 8 short papers presented were carefully reviewed and selected from 110 submissions. The papers are organized according to the following topical sections: SPI and emerging and multidisciplinary approaches to software engineering; digitalisation of industry, infrastructure and e-mobility; SPI and good/bad SPI practices in improvement; SPI and functional safety and cybersecurity; SPI and agile; SPI and standards and safety and security norms; SPI and team skills and diversity; SPI and recent innovations; virtual reality and augmented reality.